Kuopion liikuntalääketieteen tutkimuslaitoksen julkaisut

ALKUPERÄISJULKAISUT

2011
Menning et al.: Discovery of genetic variants implicated in insulin resistance through novel applica-tion of a genome-wide approach that accounts for body mass index and SNP by body mass index interaction on fasting glycemic traits.

Eloranta AM, Lindi V, Schwab U, Kiiskinen S, Kalinkin M, Lakka HM, Lakka TA. Dietary factors and their associations with socioeconomic background in Finnish girls and boys 6–8 years of age: the PANIC Study. Eur J Clin Nutr. 2011 Nov;65(11):1211-8.

Kilpeläinen TO et al. Physical activity attenuates the influence of FTO variants on obesity risk; a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 2011 Nov;8(11).

Döring F, Onur S, Kürbitz C, Boulay MR, Pérusse L, Rankinen T, Rauramaa R, Wolfarth B, Bouchard C. Single nucleotide polymorphisms in the myostatin (MSTN) and muscle creatine kinase (CKM) genes are not associated with elite endurance performance. Scand J Med Sci Sports. 2011 Dec;21(6):841-845.

Savonen K, Krachler B, Hassinen M, Komulainen P, Kiviniemi V, Lakka TA, Rauramaa R. The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study. Int J Obes (Lond). 2011 Nov 22.

Rauramaa R, Hassinen M. Exercise training and endothelial function. Curr CardiovascRisk Rep 2011;5:323-330.

Hakola L, Komulainen P, Hassinen M, Savonen K, Litmanen H, Lakka TA, Rauramaa R: Cardiorespiratory fitness in aging men and women: the DR’s EXTRA study. Scand J Med Sci Sports. 2011 Oct;21(5):679-87.

Calabresi L, Baldassarre D, Simonelli S, Gomaraschi M, Amato M, Castelnuovo S, Frigerio B, Ravani A, Sansaro D, Kauhanen J, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Veglia F, Sirtori CR, Franceschini G, Tremoli E. Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk. J Lipid Res. 2011 Aug;52(8):1569-74.

Savonen KP, Kiviniemi V, Laaksonen DE, Lakka TA, Laukkanen JA, Tuomainen TP, Rauramaa R. Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men. J Intern Med. 2011 Jul 30. doi: 10.1111/j.1365-2796.2011.02434.x.

Penttilä I, Penttilä K, Halonen T, Pulkki K, Törrönen J, Rauramaa R. Adaptiation of the Diazyme Direct Enzymatic HbA1c Assay for a microplate reader at room temperature. Clin Chem Lab Med. 2011 Jul;49(7):1221-3.

Penttilä I. "Ihminen on sitä mitä hän syö", kirjoitti Vesa Saarinen vuonna 2008. Kliin.Lab 6/2011;111-112.

Penttilä I, Halonen T. HbA1c:n rinnakkaistulostuksesta luopuminen ja uudet laadunvalvonnan tavoiterajat. Kliin.Lab 6/2011;117.

Penttilä I, Halonen T. HbA1c-analytiikka ja Labquality Oy:n kierrosten laatu. Moodi 2/2011;55-59.

Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Piras MG, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood WH 3rd, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M, Cucca F, Uda M, Schlessinger D, Nagaraja R, Abecasis GR. Fine mapping of five Loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet. 2011 Jul;7(7):e1002198.

Laukkanen JA, Rauramaa R, Mäkikallio TH, Toriola AT, Kurl S. Intensity of leisure-time physical activity and cancer mortality in men. Br J Sports Med. 2011 Feb;45(2):125-9.

Kouki R, Schwab U, Hassinen M, Komulainen P, Heikkilä H, Lakka TA, Rauramaa R.
Food consumption, nutrient intake and the risk of having metabolic syndrome:
the DR's EXTRA Study. Eur J Clin Nutr. 2011 Mar;65(3):368-77.

2010
Kouki R, Schwab U, Lakka TA, Hassinen M, Savonen K, Komulainen P, Krachler B,
Rauramaa R. Diet, Fitness and Metabolic Syndrome – The DR's Extra Study. Nutr Metab Cardiovasc Dis. 2010 Dec 24.

Laukkanen JA, Mäkikallio TH, Rauramaa R, Kiviniemi V, Ronkainen K, Kurl S. Cardiorespiratory fitness is related to the risk of sudden cardiac death: a population-based follow-up study. J Am Coll Cardiol. 2010 Oct 26;56(18):1476-83.

Döring FE, Onur S, Geisen U, Boulay MR, Perusse L, Rankinen T, Rauramaa R, Wolfahrt B, Bouchard C: ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study. J Sports Sci. 2010 Sep 14:1-5.

Komulainen P, Kivipelto M, Lakka TA, Savonen K, Hassinen M, Kiviniemi Y, Hänninen T, Rauramaa R: Exercise, fitness and cognition – A randomised controlled trial in older individuals: the DR's EXTRA study. Eur Geriatr Med 2010. Eur Geriatr Med 2010:1:266-272.

Savonen K: Liikkumattomasta liikkujaksi - hitaasti kiihdyttäen. Liikunta ja tiede 2010;47(5):28-31.

Döring F, Onur S, Kürbitz C, Boular MR, Pérusse L, Rankinen T, Rauramaa R, Wolfarth B, Bouchard C: Single nucleotide polymorphisms in the myostatin (MSTN) and muscle craetine kinase (CKM) genes are not associated with elite endurance performance. Scand J Med Sci Sports. 2010 Jun 1.

Länsimies-Antikainen H, Pietilä AM, Laitinen T, Kiviniemi V, Rauramaa R: Is informed consent related to success in exercise and diet intervention as evaluated at 12 months? DR's EXTRA study. BMC Med Ethics. 2010 Jun 8;11:9.

Länsimies-Antikainen H, Laitinen T, Rauramaa R, Pietilä AM. Evaluation of informed consent in health research: a questionnaire survey. Scand J Caring Sci. 2010 Mar;24(1):56-64.

Länsimies-Antikainen H, Pietilä AM, Kiviniemi V, Rauramaa R, Laitinen T. Evaluation of participant comprehension of information received in an exercise and diet intervention trial: The DR's EXTRA study. Gerontology. 2010;56(3):291-7.

Hassinen M, Lakka TA, Hakola L, Savonen K, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, Rauramaa R: Cardiorespiratory fitness and metabolic syndrome in older men and women:the dose responses to Exercise Training (DR's EXTRA) study. Diabetes care 2010 Jul;33(7):1655-7.

Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Mursu J, Savonen K, Lakka TA, Niskanen L, Kauhanen J: Sedentary lifestyle and emergence of hopelessness in middle-aged men. European Journal of Cardiovascular Prevention and Rehabilitation, 2010 Oct;17(5):524-9.

Döring F, Onur S, Fischer A, Boulay MR, Pérusse L, Rankinen T, Rauramaa R, Wolfarth B, Bouchard C: A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1alpha (HIF1A) gene in elite endurance athletes. J Appl Physiol. 2010 Jun;108(6):1497-500.

Baldassarre D, Nyyssönen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral G, Grossi E, Veglia F, Paoletti R, Tremoli E, on behalf of the IMPROVE study group. Cross-sectional analysis of baseline data to identify the major determinants of carotid intima–media thickness in a European population: the IMPROVE study. Eur Heart J 2010; 31, 614–622.

Laukkanen JA, Pukkala E, Rauramaa R, Mäkikallio TH, Toriola AT, Kurl S. Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in Finnish men. Eur J Cancer. 2010:46:355-363.

Savonen K. Heart rate response to exercise and cardiovascular health in men: A prospective population study. Saarbrücken: VDM Verlag. 2010. Kirja

2009

Baldassarre D, Nyyssönen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Grossi E, Veglia F, Paoletti R, Tremoli E, Laukkanen JA, Rauramaa R, Mäkikallio TH, Toriola AT, Kurl S. Intensity of leisure-time physical activity and Cancer mortality in men. Br J Sports Med. 2009 Jul 28.

Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Kauhanen J, Lakka T, Niskanen L. Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men. BMC Public Health. 2009 Jun 25;9:204

Laukkanen JA, Laaksonen D, Lakka TA, Savonen K, Rauramaa R,Mäkikallio T, Kurl S. Determinants of cardiorespiratory fitness in men aged 42 to 60 years with and without cardiovascular disease. Am J Cardiol. 2009 Jun1;103(11):1598-604.

Laukkanen JA, Mäkikallio T, Rauramaa R, Kurl S. Asymptomatic St-segment depression during exercise testing and the risk of sudden cardiac death in middle-aged men: a population-based follow-up study. Eur Heart J. 2009 Mar;30(5):558-65.

Kurl S, Sivenius J, Mäkikallio T, Rauramaa R, Laukkanen A. Exercise workload, cardiovascular risk factor evaluation and the risk of stroke in middle-aged men. J Inter Med. 2009 Feb;265(2):229-37.
  
 2008
Kurl S, Sivenius J, Mäkikallio TH, Rauramaa R, Laukkanen JA. Exercise workload, cardiovascular risk factor evaluation and the risk of stroke in middle-aged men. J Intern Med 2009;265(2):229-237.

Laukkanen JA, Rauramaa R, Kurl S. Exercise workload, coronary risk evaluation and the risk of cardiovascular and all-cause death in middle-aged men. Eur J Cardiovasc Prev Rehabil. 2008;15(3):285-92.

de Mello VD, Kolehmainen M, Pulkkinen L, Schwab U, Mager U, Laaksonen DE, Niskanen L, Gylling H, Atalay M, Rauramaa R, Uusitupa M. Downregulation of genes involved in NF?B activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study. Diabetologia. 2008;51(11):2060-7. 

Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R. BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study. Neurobiol Learn Mem. 2008;90(4):596-603. 

Savonen KP, Kiviniemi V, Laukkanen JA, Lakka TA, Rauramaa TH, Salonen JT, Rauramaa R. Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease. Eur Heart J. 2008;29(15):1896-902.

Mäkinen VP, Forsblom C, Thorn LM, Wadén J, Gordin D, Heikkilä O, Hietala K, Kyllönen L, Kytö J, Rosengård-Bärlund M, Saraheimo M, Tolonen N, Parkkonen M, Kaski K, Ala-Korpela M, Groop PH; FinnDiane Study Group. Metabolic phenotypes, vascular complications, and premature deaths in a population of 4,197 patients with type 1 diabetes. Diabetes 2008;57(9):2480-7.  

Saraheimo M, Forsblom C, Thorn L, Wadén J, Rosengård-Bärlund M, Heikkilä O, Hietala K, Gordin D, Frystyk J, Flyvbjerg A, Groop PH; FinnDiane Study Group. Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes. Diabetes Care 2008;31(6):1165-9.
Laukkanen JA, Rauramaa R, Kurl S. Exercise workload, coronary risk evaluation and the risk of cardiovascular and all-cause death in middle-aged men. Eur J Cardiovasc Prev Rehabil. 2008;15:285-292.

Laaksonen DE, Niskanen L, Mykkänen H, Juntunen KS, Schwab U, Kolehmainen M, Rauramaa R, Tuomilehto J, Uusitupa M. Long-term repeatability of measures of early insulin secretion derived from an intravenous glucose tolerance test and conversion from impaired glucose tolerance to diabetes. Ann Med. 2008;40:303-11.

Penttilä IM: Tulevatko apolipoproteiinimääritykset syrjäyttämään kolesterolimääritykset? Kliin?Lab 2008;25:49-50.

Mager U, Kolehmainen M, de Mello VD, Schwab U, Laaksonen DE, Rauramaa R, Gylling H, Atalay M, Pulkkinen L, Uusitupa M. Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome. European Journal of Endocrinology 2008;158:499–510.

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Usefulness of chronotropic incompetence in response to exercise as a predictor of myocardial infarction in middle-aged men without cardiovascular disease. Am J Cardiol. 2008;101:992-8.

Lappalainen T, Kolehmainen M, Schwab U, Pulkkinen L, Laaksonen DE, Rauramaa R, Uusitupa M, Gylling H. Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study. Eur J Endocrinol. 2008;158:333-41.

Borodulin K, Laatikainen T, Lahti-Koski M, Jousilahti P, Lakka TA. Association of age and education with different types of leisure-time physical activity among 4437 Finnish adults. J Phys Act Health. 2008;5:242-51.

Hassinen M, Lakka TA, Savonen K, Litmanen H, Kiviaho L, Laaksonen DE, Komulainen P, Rauramaa R. Cardiorespiratory Fitness as a Feature of the Metabolic Syndrome in Older Men and Women: The DR's EXTRA Study. Diabetes Care 2008;31:1242-7.

de Mello VD, Kolehmainen M, Schwab U, Mager U, Laaksonen DE, Pulkkinen L, Niskanen L, Gylling H, Atalay M, Rauramaa R, Uusitupa M. Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome. Metabolism 2008;57:192-9.

Laaksonen DE, Niskanen L, Nyyssönen K, Lakka TA, Laukkanen JA, Salonen JT. Dyslipidaemia as a predictor of hypertension in middle-aged men. Eur Heart J. 2008 Feb 28. [Epub ahead of print]

Kilpeläinen TO, Lakka TA, Laaksonen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M; Finnish Diabetes Prevention Study Group. Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study. Metabolism. 2008 Mar;57(3):428-36.

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH; FinnDiane Study Group. Physical activity and diabetes complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study. Diabetes Care. 2008;31:230-2.

Penttilä IM: Glykoituneiden proteiinimääritysten historiaa. Moodi 1/2008.
Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Med Sci Sports Exerc. 2008;40:25-33.

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Workload at the Heart Rate of 100 Beats/min and Mortality in Middle-Aged Men with Known or Suspected Coronary Heart Disease. Heart. 2008;94:e14.

Kolehmainen M, Salopuro T, Schwab U S, Kekäläinen J , Kallio P, Laaksonen DE, Pulkkinen L,  Lindi V I , Sivenius K,  Mager U, Siitonen N,  Niskanen L,  Gylling H, Rauramaa R, Uusitupa M. Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study. Int J Obes (Lond). 2008;32:292-303.

Wolfarth B, Rankinen T, Mühlbauer S, Ducke M, Rauramaa R, Boulay MR, Pérusse L, Bouchard C. Endothelial nitric oxide synthase gene polymorphism and elite endurance athlete status: the
Genathlete study. Scand J Med Sci Sports. 2008 Aug;18(4):485-90.

Penttilä IM, Savolainen K, Lampinen H, Lukkarinen J. Easily Applicable Myoglobin Method on the KonelabTM Analyzer. Klin Biokemi i Norden 2008;20:44-46. 

2007

Wolfarth B, Rankinen T, Mühlbauer S, Scherr J, Boulay MR, Pérusse L, Rauramaa R, Bouchard C. Association between a beta2-adrenergic receptor polymorphism and elite endurance performance. Metabolism. 2007;56:1649-51.

Penttilä I: Homokysteiini, määritys ja kliniset sovellukset. Kliin?Lab 24/2007.
Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics. 2007;31:264-72.

Hu G, Jousilahti P, Borodulin K, Barengo NC, Lakka TA, Nissinen A, Tuomilehto J. Occupational, commuting and leisure-time physical activity in relation to coronary heart disease among middle-aged Finnish men and women. Atherosclerosis. 2007;194:490-7.

Komulainen P, Kivipelto M, Lakka TA, Hassinen M, Helkala EL, Patja K, Nissinen A, Rauramaa R. Carotid Intima-Media Thickness and Cognitive Function in Elderly Women: a Population-Based Study. Neuroepidemiology. 2007;28:207-213.

Karppi J, Kerman S, Kerman K, Sundell A, Nyyssonen K, Penttila I. Isolation of drugs from biological fluids by using pH sensitive poly(acrylic acid) grafted poly(vinylidene fluoride) polymer membrane in vitro. Eur J Pharm Biopharm. 2007;67:562-8.

Hassinen M, Lakka TA, Komulainen P, Haapala I, Nissinen A, Rauramaa R. Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women. Int J Obes (Lond). 2007;31:1406-11.

Penttilä IM, Laatikainen A, Penttila K, Punnonen K, Rantanen T, Savolainen K, Tiikkainen U. Imprecision of cardiac marker analyses among laboratories on the basis of external quality assurance results: Finnish experience. Scand J Clin Lab Invest. 2007;67:507-18.

Ilkka Penttilä: "Olisiko syytä seuloa sydämen vajaatoiminnan riskiä?". Kliin?Lab 2/2007 Vol 24.

Ilkka Penttilä: "IFCC:n suositusehdotus glykohemoglobiinimäärityksen uudeksi nimeksi ja yksiköksi". Pääkirjoitus Kliin?Lab, 2007;24:51.

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline. Am J Cardiol. 2007;100:563-8.

Laukkanen JA, Rauramaa R, Salonen JT, Kurl S. The predictive value of cardiorespiratory fitness combined with coronary risk evaluation and the risk of cardiovascular and all-cause death. J Intern Med. 2007;262:263-72.

Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H. Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. Clin Chim Acta. 2007;383:126-32.

Karppi J, Akerman S, Akerman K, Sundell A, Nyyssonen K, Penttila I. Adsorption of drugs onto a pH responsive poly(N,N-dimethyl aminoethyl methacrylate) grafted anion-exchange membrane in vitro. Int J Pharm. 2007;338:7-14.

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. Cholesterol synthesis prevails over absorption in metabolic syndrome. Transl Res. 2007;149:310-6.

Länsimies-Antikainen H, Pietilä AM, Laitinen T, Schwab U, Rauramaa R, Länsimies E. Evaluation of informed consent: a pilot study. J Adv Nurs. 2007;59:146-54.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007;36:443-8.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala EL, Haapala I, Nissinen A, Rauramaa R. Metabolic  Syndrome and Cognitive Function: a Population-Based Follow-up Study in Elderly Women. Dement Geriatr Cogn. Disord 2007;23:29-34. 
  
2006
Hallikainen M, Lyyra-Laitinen T, Laitinen T, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H. Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters. Atherosclerosis 2006;188:425-32. 

Laukkanen JA, Kurl S, Salonen JT, Lakka TA, Rauramaa R. Peak oxygen pulse during exercise as a predictor for coronary heart disease and all-cause death in men. Heart. 2006;92: 1219-24.  

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. C-reactive Protein and Metabolic Syndrome in Elderly Women. A 12-year follow-up study. Diabetes Care. 2006;29:931-2. 

Savonen K, Lakka TA, Laukkanen J, Rauramaa T, Salonen JT, Rauramaa R. Heart Rate Response During Exercise Test and Cardiovascular Mortality in Middle-Aged Men. Eur Heart J. 2006;27:582-8.   

Laukkanen JA, Kurl S, Rauramaa R, Lakka TA, Venäläinen JM, Salonen JT. Systolic Blood Pressure Response to Exercise Testing Is Related to the Risk of Acute Myocardial Infarction in Middle-Aged Men. Eur J Cardiov Prev R. 2006;13:421-428. 

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Haapala I, Gylling H, Alen M, Schmidt-Trucksäss A, Nissinen A, Rauramaa R. Metabolic Syndrome and the Progression of Carotid Intima-Media Thickness in Elderly Women. Arch Int Med.  2006;166:444-9.

Penttilä I, Hongisto T, Savolainen K ja Tiikkainen U: "Sydänmerkkiaineiden laatu Labquolity Oy:n tulosten valossa". Kliin.Lab 1/2006.

2005

Penttilä IM, Halonen T, Punnonen K, Tiikkainen U. Best use of the recommended IFCC reference method, material and values in HbA1C analyses. Scand J Clin Lav Invest 2005;65:453-462.

Tuomainen P, Peuhkurinen K, Kettunen R, Rauramaa R. Regular physical exercise, heart rate variability and turbulence in a 6-year randomized controlled trial in middle-aged men: The DNASCO Study. Life Sci. 2005;77:2723-34.

Remes T, Väisänen SB, Mahonen A, Huuskonen J, Kröger H, Jurvelin JS, Rauramaa R. Bone mineral density, body height, and vitamin D receptor gene polymorphism in middle-aged men. Ann Med 2005;37:383-392.

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. Associations of Body Composition and Physical activity with Balance and Walking Ability in the Elderly. Journal of Physical Activity and Health 2005;3:298-306.

Kurl S, Laukkanen JA, Niskanen L, Rauramaa R, Tuomainen TP, Sivenius J, Salonen JT. Cardiac power during exercise and the risk of stroke. Stroke 2005;36:820-4.

2004

Laukkanen JA, Kurl S, Salonen R, Lakka TA, Rauramaa R, Salonen JT. Systolic Blood Pressure During Recovery From Exercise and the Risk of Acute Myocardial Infarction in Middle-Aged Men.  Hypertension 2004;44:820-825.

Rauramaa R, Halonen P, Lakka TA. Aerobic physical exercise and atherosclerosis in men. Letter. Ann Int Med 2004;141:890.

Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J. 2004;25:1428-37.

Remes T, Väisänen SB, Mahonen A, Huuskonen J, Kroger H, Jurvelin JS, Penttila IM, Rauramaa R.The association of bone metabolism with bone mineral density, serum sex hormone concentrations, and regular exercise in middle-aged men. Bone. 2004;35:439-47.

Gylling H, Hallikainen M, Pihlajamäki J,  Ågren J, Laakso M,  Rajaratnam R , Rauramaa R, and  Miettinen TA: Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res. 2004;45:1660-5.

Rauramaa R, Halonen P, Väisänen SB, Lakka TA, Schmidt-Trucksäss A, Berg A, Penttilä IM, Rankinen T, Bouchard C. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Int Med. 2004;140:1007-1014. 

Uusitalo AL, Laitinen T, Väisänen SB, Länsimies E, Rauramaa R. Physical training and heart rate and blood pressure variability - a five-year randomized trial. Am J Physiol Heart Circ Physiol. 2004;286:H1821-6. 

Penttilä I. Glykoituneen hemoglobiiinin määritykset, niiden laatu sekä analyysien tulevaisuudennäkymät Suomessa. Moodi 2004;28:94–96.

Penttilä I, Tiikkainen U. Glykoituneen hemoglobiinin määritykset ja niiden laatu sekä analyysien tulevaisuuden näkymät Suomessa. Kliin?Lab2004;21:99-102.

2003:
Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Salonen R, Rauramaa R, Salonen JT. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol. 2003;149:601-8. 

Karpansalo M, Lakka TA, Manninen P, Kauhanen J, Rauramaa R, Salonen JT. Cardiorespiratory fitness and risk of disability pension: a prospective population based study in Finnish men. Occup Environ Med. 2003;60:765-9. 

Lakka TA, Laaksonen DE, Lakka H-M, Mannikko N, Niskanen LK, Rauramaa R, Salonen JT. Sedentary Lifestyle, Poor Cardiorespiratory Fitness and the Metabolic Syndrome. Med Sci Sports Exerc. 2003;35: 1279-86.  

Kurl S, Laukkanen JA, Tuomainen T-P, Rauramaa R, Lakka TA, Salonen JT, Eränen J, Sivenius J, Salonen JT. Association of Exercise-Induced Silent ST-Segment Depression With the Risk of Stroke and Cardiovascular Diseases in Men. Stroke 2003;34:1760-5. 

Laaksonen DE, Lakka H-M, Lynch J, Lakka TA, Niskanen L, Rauramaa R, Salonen JT, Kauhanen J. Cardiorespiratory Fitness and Vigorous Leisure-Time Physical Activity Modify the Association of Small Size at Birth With the Metabolic Syndrome. Diabetes Care 2003;26:2156-64. 

Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Cardiorespiratory Fitness and the Risk of Stroke in Men. Arch Int Med 2003;163:1682-8. 

Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. A Quantitative Trait Locus on 7q31 for the Changes in Plasma Insulin in Response to Exercise Training: the HERITAGE Family Study. Diabetes. 2003;52:1583-7.  

König D, Väisänen SB, Bouchard C, Halle M, Lakka TA, Baumstark MW, Alen M, Berg A, Rauramaa R. Cardiorespiratory fitness modifies the association between dietary fat intake and plasma fatty acids. European Journal of Clinical Nutrition 2003;57:810-815. 

Remes T, Väisänen SB, Mahonen A, Huuskonen J, Kröger H, Jurvelin JS, Penttilä IM, Rauramaa R. Aerobic exercise and bone mineral density in middle-aged Finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor a gene polymorphisms. Bone 2003;32:412-420.  

Schmidt-Trücksäss A, Sandrock M, Cheng da C, Müller HM, Baumstark MW, Rauramaa R, Berg A, Huonker M. Quantative measurement of carotid intima-media roughness - effect of age and manifest coronary artery disease. Atherosclerosis 2003;166:57-65.  
 
2002: 
Karpansalo M, Manninen P, Lakka TA, Kauhanen J, Rauramaa R, Salonen JT. Physical workload and risk of early retirement: prospective population-based study among middle-aged men. J Occup Environ Med. 2002;44:930-9.    
Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA. Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 2002;25:1612-1618.    
Rauramaa R, Kuhanen R, Lakka TA, Väisänen SB, Halonen P, Alen M, Rankinen T, Bouchard C. Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism. Physiol Genomics 2002;10:71-77.     
König D, Väisänen SB, Bouchard C, Halle M, Lakka TA, Baumstark MW, Alen M, Berg A, 
Rauramaa R. Cardiorespiratory fitness modifies the association between dietary fat intake and plasma fatty acids. European Journal of Clinical Nutrition 2003;57:810-815.   
Huuskonen J, Väisänen SB, Kröger H, Jurvelin JS, Penttilä I, Alhava E, Rauramaa R. The relation of sex hormones to bone mineral density in middle-aged men during a four year exercise intervention trial. Bone 2002;31:51-6.  
Hassinen M, Komulainen P. Kevytkuormitteisen aerobisen liikunnan vaikutus lihasvoimaan, nivelten liikkuvuuteen ja tasapainoon keski-ikäisillä miehillä. Fysioterapia 2002;4:25-29.   
Uusitalo ALT, Laitinen T, Väisänen SB, Länsimies E, Rauramaa R. Effects of endurance training on heart rate and blood pressure variability. Clin Physiol & Func Im 2002;22:173-179.    

2001: 
Schmidt-Trucksäss A, Cheng Dc D, Sandrock M, Schulte-Mönting J, Rauramaa R, Huonker M, Burkhardt H. Computerized analysing system using the active contour in ultrasound measurement of carotid artery intima-media thickness. Clin Physiol. 2001;21:561-569.    
Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Systolic blood pressure response to exercise stress test and risk of stroke. Stroke. 2001;32:2036-2041.     
Laukkanen JA, Kurl S, Lakka TA, Tuomainen TP, Rauramaa R, Salonen R, Eränen J, Salonen JT. Exercise-induced silent myocardial ischemia and coronary morbidity and mortality in middle-aged men.  J Am Coll Cardiol. 2001;38:72-79.     
Huuskonen J, Väisänen SB, Kröger H, Jurvelin JS, Alhava E, Rauramaa R. Regular physical exercise and bone mineral density: a four-year controlled randomized trial in middle-aged men. The DNASCO study. Osteoporos Int. 2001;12:349-355.    
Laukkanen JA, Lakka TA, Rauramaa R, Kuhanen R, Venäläinen JM, Salonen R, Salonen JT. Cardiovascular fitness as a predictor of mortality in men. Arch Intern Med. 2001;161:825-831.    
Lakka T, Laukkanen J, Rauramaa R, Salonen R, Lakka H-M, Kaplan G, Salonen J. Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med. 2001;134:12-20.    
Kuhanen R, Tainio E. Jääkiekkoilijoiden alaraajojen voimaominaisuudet - yksilöllisellä voimaharjoittelulla lisää nopeutta. Valmentaja 1/2001:14-17.  
 
2000: 
Rauramaa R, Väisänen S, Luong L-A, Schmidt-Trücksäss A, Penttilä I, Bouchard C, Töyry J, Humphries S. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20:2657-2662.    
Huuskonen J, Väisänen S, Kröger H, Jurvelin C, Bouchard C, Alhava E, Rauramaa R. Determinants of bone mineral density in middle aged men: a population-based study. Osteoporos Int 2000;11:702-708.     
Rankinen T, Hietanen E, Väisänen S, Lehtiö M, Penttilä I, Bouchard C, Rauramaa R. Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men. Thromb Res 2000;99:453-459.     
Rauramaa R, Väisänen S, Kuhanen R, Penttilä I, Bouchard C. The RsaI polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training - a  controlled randomised clinical trial in men. Thromb Haemost 2000;83:803-6.     
Niskanen L, Karvonen M, Valve R, Koulu M, Pesonen U, Mercuri M, Rauramaa R, Töyry J, Laakso M, Uusitupa M. Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects. J Clin Endocrinol Metab. 2000;85:2266-9.    
Rankinen T, Wolfarth B, Simoneau J-A, Maier-Lenz D, Rauramaa R, Rivera M, Boulay M, Chagnon Y, Perusse L, Keul J, Bouchard C. No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J Appl Physiol 2000;88:1571-1575.    

1999: 
Korhonen MH, Litmanen H, Rauramaa  R, Väisänen SB, Niskanen L, Uusitupa M. Adherence to the salt restriction diet among people with mildly elevated blood pressure. Eur J Clin Nutr 1999;53:880-5.    
Väisänen SB, Humphries SE, Luong LA, Penttilä I, Bouchard C, Rauramaa R. Regular exercise, plasminogen activator inhibitor-1 (PAI-1) activity and the 4G/5G promoter polymorphism in the PAI-1 gene. Thromb Haemost 1999;82:1117-1120.    
Helminen A, Rankinen T, Halonen P, Väisänen S, Rauramaa R. Positive and negative life changes and LDL cholesterol. J Biosoc Sci 1999;31:269-277.    
 
1998: 
Rankinen T, Lyytikäinen S, Vanninen E, Penttilä I, Rauramaa R, Uusitupa M. Nutritional status of the Finnish elite ski jumpers. Med. Sci. Sports Exerc. 1998;30:1592-1597.    
Vanninen E, Mussalo H, Vainio P, Tuomainen P, Ikonen A, Kettunen R, Rauramaa R, Kuikka JT. Sydänlihaksen perfuusion gammakuvauksen uusia mahdollisuuksia: viitearvot ja EKG-tahdistettu yksifotoniemissio-tomografia. Suom LääkL 1998;53:141-147.   
 

1997: 
Helminen A, Rankinen T, Väisänen S, Rauramaa R. Social network in relation to plasma fibrinogen. J Biosoc Sci 1997;29:129-39.   
Rankinen T, Suomela-Markkanen T, Väisänen S, Helminen A, Penttilä I, Berg A, Bouchard C, Rauramaa R. Relationship between the changes in physical activity and plasma insulin during a 2.5 year follow-up study. Metabolism 1997;46:1418-23.    
Väisänen S, Baumstark M,Penttilä I, Bouchard C, Halonen P, Rankinen T, Berg A, Rauramaa R. Small, dense LDL particle concentration correlates with plasminogen activator inhibitor type-1 (PAI-1) activity. Thromb Haemost 1997;78:1495-9.    
Vauhkonen I, Niskanen L, Ryynänen M, Voutilainen R, Partanen J, Mercuri M, Rauramaa R, Töyry J, Uusitupa M. Divergent association of apolipoprotein E polymorphism with vascular disease in patients with NIDDM and control subjects. Diabet Med. 1997;14:748-756.    
Rauramaa R, Väisänen S, Nissinen A, Rankinen T, Penttilä I, Saarikoski S,Tuomilehto J, Gagnon J, Pérusse L, Bouchard C. Physical activity, fibrinogen plasma level and gene polymorphisms in postmenopausal women. Thromb Haemost 1997;78:840-4.    
Väisänen S, Rauramaa R, Penttilä I, Rankinen T, Gagnon J,  Pérusse L,  Chagnon M, Bouchard C. Variation in plasma fibrinogen over one year: relationships with genetic polymorphisms and non-genetic factors. Thromb Haemost 1997;77:884-9.    
Eronen M, Rankinen T, Halonen P, Sulkava R, Rauramaa R, Nissinen A. Does Aging Mean a Better Life for Women? J Am Geriatr Soc 1997;45:594-7.    
Ågren JJ, Väisänen S, Hänninen O, Muller AD, Hornstra G. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. Prostaglandins Leukot Essent Fatty Acids. 1997;57:419-21.  
 
1996: 
Niskanen L, Rauramaa R, Miettinen H, Haffner SM, Mercuri M, Uusitupa M. Carotid artery intima-media thickness in elderly patients with NIDDM and in nondiabetic subjects. Stroke 1996;27:1986-1992.    
Uusitupa MIJ, Niskanen L, Luoma J, Vilja P, Mercuri M, Rauramaa R, Ylä-Herttuala S. Autoantibodies against oxidized LDL do not predict atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 1996;16:1236-1242.    
Väisänen S, Rauramaa R, Rankinen T, Gagnon J, Bouchard C. Physical activity, fitness, and plasma fibrinogen with reference to fibrinogen genotypes. Med Sci Sports Exerc 1996;28:1165-1170.    
Väisänen S, Rauramaa R, Rankinen T, Gagnon J, Bouchard C. Physical activity, fitness, and plasma fibrinogen with reference to fibrinogen genotypes. Med Sci Sports Exerc 1996;28:1165-1170.  
Uusitupa M, Korhonen M, Litmanen H, Niskanen L, Väisänen S, Rauramaa R. Effects of moderate salt restriction alone and in combination with cilazapril on office and ambulatory blood pressure. J Human Hypertens 1996;10:319-326.    
 

1995: 
Helminen A, Rankinen T, Mercuri M, Rauramaa R. Carotid atherosclerosis in middle-aged men. Relation to conjugal circumstances and social support. Scand J Soc Med 1995;23:167-72.    
Huupponen MR, Mäkinen LH, Hyvönen PM, Sen CK, Rankinen T, Väisänen S, Rauramaa R. The effect of N-acetylcysteine on exercise-induced priming of human neutrophils. A chemiluminescence study. Int J Sports Med. 1995;16:399-403.    
Pekkanen J, Mutanen M, Räsänen L, Rauramaa R, Nissinen A. Association of factor VII activity with dietary fat and blood lipids among elderly men - The Finnish cohorts of the Seven Countries Study. Nutr Metab Cardiovasc Dis 1995;5:149-154.    
Rankinen T, Fogelmholm M, Kujala U, Rauramaa R, Uusitupa M. Dietary intake and nutritional status of athletic and nonathletic children in early puberty. Int J Sport Nutr. 1995;5:136-50.    
Helminen A, Halonen P, Rankinen T, Nissinen A, Rauramaa R. Validity assesment of a social support index. Scand J Soc Med 1995;23:66-74.    
Rankinen T, Väisänen S, Penttilä I, Rauramaa R. Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost 1995r:73:281-286.    
Rauramaa R, Väisänen SB, Rankinen T, Penttilä IM, Saarikoski S, Tuomilehto J, Nissinen A. Inverse relation of physical activity and apolipoprotein AI to blood pressure in elderly women. MSSE 1995;27:164-169.    
Rauramaa R, Rankinen T, Tuomainen P, Väisänen S, Mercuri M. Inverse relationship between cardiorespiratory fitness and carotid atherosclerosis in middle-aged men. Atherosclerosis 1995;112:213-221.    
Rauramaa R, Tuomainen P, Väisänen S, Rankinen T. Physical activity and health-related fitness in middle-aged men. MSSE 1995;27:707-712.    
Väisänen S, Rankinen T, Penttilä I, Rauramaa R. Factor VII coagulant activity in relation to serum lipoproteins and dietary fat in middle-aged men. Thromb Haemost 1995;73:435-8.    
 
1994: 
Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med 1994;330:1549-54.    
Rauramaa R, Väisänen S, Mercuri M, Rankinen T, Penttilä I, Bond MG. Association of risk factors and body iron status to carotid atherosclerosis in middle-aged Eastern Finnish men. Eur Heart J 1994;15:1020-1027.    
Rauramaa R, Väisänen S, Penttilä I, Rankinen T. Inverse relationship between dietary starch intake and plasma fibrinogen in middle-aged men. Nutr Metab Cardiovasc Dis 1994;4:192-196.   
Rankinen T, Rauramaa R, Väisänen S, Halonen P, Penttilä IM. Blood coagulation and fibrinolytic factors are unchanged by aerobic exercise or fat modified diet. Fibrinolysis 1994;8:48-53.     
Sen CK, Rankinen T, Väisänen S, Rauramaa R. Oxidative stress after human exercise: effect of N-acetylcysteine supplementation. J Appl Physiol. 1994;76:2570-2577.     
Rankinen T, Väisänen S, Mercuri M, Rauramaa R. Apolipoprotein(a), Fibrinopeptide A and carotid atherosclerosis in middle-aged men. Thromb Haemost 1994;72:563-6.    
Rankinen T, Rauramaa R, Väisänen S, Penttilä IM, Uusitupa M. Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thromb Haemost 1994;71:180-183.    

1993: 
Rankinen T, Rauramaa R, Väisänen S, Penttilä I, Saarikoski S, Tuomilehto J, Nissinen A. Inverse relationship between physical activity and plasma fibrinogen in postmenopausal women. Atherosclerosis 1993;102:181-186.