Vertaisarvioidut artikkelit

2023

Nguyen DTA, Julkunen P, Säisänen L, Määttä S, Rissanen SM, Lintu N, Könönen M, Lakka T, Karjalainen PA. Developmental models of motor-evoked potential features by transcranial magnetic stimulation across age groups from childhood to adulthood Sci Rep. 2023 Jun 30;13(1):10604. doi: 10.1038/s41598-023-37775-w. PMID: 37391521 

Saijonkari M, Paronen E, Lakka T, Tolmunen T, Linnosmaa I, Lammintakanen J, Isotalo J, Rekola H, Mäki-Opas T. Promotive and preventive interventions for mental health and well-being in adult populations: a systematic umbrella review Front Public Health. 2023 Aug 31;11:1201552. doi: 10.3389/fpubh.2023.1201552. eCollection 2023.
PMID: 37719731 

Riekki H, Aitokari L, Kivelä L, Lahti S, Hiltunen P, Vuorela N, Huhtala H, Lakka TA, Kurppa K. Prevalence and associated factors of metabolic-associated fatty liver disease in overweight Finnish children and adolescents Front Endocrinol (Lausanne). 2023 Jun 20;14:1090344. doi: 10.3389/fendo.2023.1090344. eCollection 2023. PMID: 37409224 

de Las Fuentes L, Schwander KL, Brown MR,...Rauramaa R, Komulainen P, Timo A Lakka, et al. Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci  Front Genet. 2023 Nov 2;14:1235337. doi: 10.3389/fgene.2023.1235337. eCollection 2023. PMID: 38028628

Medina-Gomez C, Mullin BH, Chesi A, ...Lakka TA.. et al. Bone mineral density loci specific to the skull portray potential pleiotropic effects on craniosynostosis  Commun Biol. 2023 Jul 4;6(1):691. doi: 10.1038/s42003-023-04869-0. PMID: 37402774 

Aira T, Vasankari T, Heinonen OJ, Korpelainen R, Kotkajuuri J, Parkkari J, Savonen K, Toivo K, Uusitalo A, Valtonen M, Villberg J, Vähä-Ypyä H, Kokko SP. Psychosocial and health behavioural characteristics of longitudinal physical activity patterns: a cohort study from adolescence to young adulthood BMC Public Health. 2023 Nov 3;23(1):2156. doi: 10.1186/s12889-023-17122-4.
PMID: 37924075 

Rinta-Antila K, Koski P, ..., Savonen K, Toivo K, Uusitalo A, Valtonen M, Vasankari T, Villberg J, Kokko S. Sports-related factors predicting maintained participation and dropout in organized sports in emerging adulthood: a four-year follow-up study. Scand J Med Sci Sports 2023 (Epub ahead of print). 

Heikkilä L, Korpelainen R, ..., Parkkari J, Savonen K, Valtonen M, Vasankari T, Villberg J, Vanhala M. Is health promotion in sports clubs associated with adolescent participants’ fruit and vegetable consumption? Eur J Public Health 2023 (Epub ahead of print). 

Csader S, Chen X, Leung H, Männistö V, Pentikäinen H, Tauriainen MM, Savonen K, El-Nezami H, Schwab U, Panagiotou G. Gut ecological networks reveal associations between bacteria, exercise, and clinical profile in non-alcoholic fatty liver disease patients. mSystems 2023 (Epub ahead of print). 

Naveed S, Sallinen T, ..., Pentikäinen H, Savonen K, Lakka TA, Haapala EA. Effects of 2-year dietary and physical activity intervention on cognition in children-a nonrandomized controlled trial. Scand J Med Sci Sports 2023 (Epub ahead of print). 

Chen QS, Bergman O, ..., Savonen K, Lind L, Eriksson P, Gigante B; IMPROVE study group. A machine learning based approach to identify carotid subclinical atherosclerosis endotypes. Cardiovasc Res 2023 (Epub ahead of print).

Williamson A, Lakka T. et al. Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake. Nat Genet 2023;55:973-983.

Aira T, Kokko SP, Heinonen OJ, Korpelainen R, Kotkajuuri J, Parkkari J, Savonen K, Toivo K, Uusitalo A, Valtonen M, Villberg J, Niemelä O, Vähä-Ypyä H, Vasankari T. Longitudinal physical activity patterns and the development of cardiometabolic risk factors during adolescence. Scand J Med Sci Sports 2023;33:1807-1820. 

Csader S, Ismaiah MJ, ..., Männistö V, Pentikäinen H, Savonen K, Tauriainen MM, Galano JM, ...et al. Twelve weeks of high-intensity interval training alters adipose tissue gene expression but not oxylipin levels in people with non-alcoholic fatty liver disease. Int J Mol Sci 2023;24:8509. 

Maitusong B, Laguzzi F, Strawbridge RJ, Baldassarre D, Veglia F, Humphries SE, Savonen K, Kurl S, ...et al; IMPROVE Study group. Cross-sectional gene-smoking interaction analysis in relation to subclinical atherosclerosis - results from the IMPROVE study. Circ Genom Precis Med 2023;16:236-247. 

Nève G, Komulainen P, Savonen K, Hassinen M, Männikkö R, Infanger D, Schmidt-Trucksäss A, Rauramaa R. Effect of lifestyle interventions on carotid arterial structure - The DR's EXTRA study  Prev Med. 2023 Jan 29;168:107436. doi: 10.1016/j.ypmed.2023.107436. Online ahead of print. PMID: 36724843

Saner C, Senior AM, Zhang H, ... Raubenheimer D, Lakka TA. Evidence for protein leverage in a general population sample of children and adolescents  Eur J Clin Nutr. 2023 Feb 16. doi: 10.1038/s41430-023-01276-w. Online ahead of print. PMID: 36797489

Haapala EA, Kuronen E, Ihalainen JK, Lintu N, Leppänen MH, Tompuri T, Atalay M, Schwab U, Lakka TA. Cross-sectional associations between physical fitness and biomarkers of inflammation in children - the PANIC Study Scand J Med Sci Sports. 2023 Feb 13. doi: 10.1111/sms.14337. Online ahead of print. PMID: 36779507

Skinner AM, Vlachopoulos D, Barker AR, Moore SA, ... Brage S, Lakka TA. Physical activity volume and intensity distribution in relation to bone, lean and fat mass in children Scand J Med Sci Sports. 2023 Mar;33(3):267-282. doi: 10.1111/sms.14255. Epub 2022 Nov 17.
PMID: 36326758

Ortega FB, Leskošek B, Blagus R, Gil-Cosano JJ, Mäestu J,...Lakka TA, et al.; FitBack, HELENA and IDEFICS consortia. European fitness landscape for children and adolescents: updated reference values, fitness maps and country rankings based on nearly 8 million test results from 34 countries gathered by the FitBack network Br J Sports Med. 2023 Mar;57(5):299-310. doi: 10.1136/bjsports-2022-106176. Epub 2023 Jan 9. PMID: 36623866 

Lakka TA, Aittola K, Järvelä-Reijonen E, Tilles-Tirkkonen T, Männikkö R, et al. Real-world effectiveness of digital and group-based lifestyle interventions as compared with usual care to reduce type 2 diabetes risk - A stop diabetes pragmatic randomised trial Lancet Reg Health Eur. 2023 Jan;24:100527. doi: 10.1016/j.lanepe.2022.100527. Epub 2022 Oct 12. PMID: 36620354 

2022

Rinta-Antila K, Koski P, Heinonen OJ, ..., Savonen K, ..., Villberg J, Kokko S. Sports club participation patterns from adolescence to emerging adulthood and their educational and family-related determinants – a four-year follow-up study. Int J Health Promot Educ (Online ahead of print)

Toivo K, Vähä-Ypyä H, ..., Savonen K, Selänne H, Kokko S, Kujala UM, Villberg J, Vasankari T. Physical activity measured by accelerometry among adolescents participating in sports clubs and non-participating peers. Eur J Sport Sci 2022 (Online ahead of print). 

Haapala EA, Väistö J, ..., Schwab U, Brage S, Atalay M, Lakka TA. Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children Eur J Sport Sci. 2022;22:906-915. doi: 10.1080/17461391.2021.1892830. Epub 2021 Mar 14.

Haapala EA, Leppänen MH, Lehti M, Lintu N, Tompuri T, Viitasalo A, Schwab U, Lakka TA. Cross-sectional associations between cardiorespiratory fitness and NMR-derived metabolic biomarkers in children - the PANIC study  Front Endocrinol (Lausanne). 2022 Sep 23;13:954418. doi: 10.3389/fendo.2022.954418. eCollection 2022.
PMID: 36213296

Soininen S, Eloranta AM, Schwab U, Lakka TA. Sources of vitamin D and determinants of serum 25-hydroxyvitamin D in Finnish adolescents  Eur J Nutr. 2022 Nov 9. doi: 10.1007/s00394-022-03039-y. Online ahead of print. PMID: 36350359

Vaajoki A, Turjamaa R, Lakka T, Mäkinen E, Välimäki T. A participatory arts programme - Shared experience for family caregivers and care recipients  Nurs Open. 2022 Dec 12. doi: 10.1002/nop2.1547. Online ahead of print. PMID: 36504364

Mäkituomas L, Heikkilä L, Nurkkala M, Korpelainen R, Alanko L, Heinonen OJ, Kokko S, Kujala U, Parkkari J, Savonen K, Valtonen M, Vasankari T, Villberg J, Vanhala M. Factors associated with body size perception among adolescent goal-oriented sports participants and non-participants: a cross-sectional Finnish study  BMC Public Health. 2022 Nov 25;22(1):2188. doi: 10.1186/s12889-022-14511-z.
PMID: 36434562 

Haapala EA, Tompuri T, Lintu N, Viitasalo A, Savonen K, Lakka TA, Laukkanen JA. Is low cardiorespiratory fitness a feature of metabolic syndrome in children and adults?  J Sci Med Sport. 2022 Nov;25(11):923-929. doi: 10.1016/j.jsams.2022.08.002. Epub 2022 Aug 4. PMID: 35989176

Nève G, Komulainen P, Savonen K, Hassinen M, Männikkö R, Infanger D, Schmidt-Trucksäss A, Rauramaa R. Adherence to Life's simple 7 is associated with better carotid properties Atherosclerosis. 2022 Nov;360:21-26. doi: 10.1016/j.atherosclerosis.2022.09.010. Epub 2022 Sep 30. PMID: 36228449

Vähä-Ypyä H, Sievänen H, Husu P, Tokola K, Mänttäri A, Heinonen OJ, Heiskanen J, Kaikkonen KM, Savonen K, Kokko S, Vasankari T. How adherence to the updated physical activity guidelines should be assessed with accelerometer?  Eur J Public Health. 2022 Aug 26;32(Suppl 1):i50-i55. doi: 10.1093/eurpub/ckac078.
PMID: 36031824

Constable AM, Vlachopoulos D, Barker AR, Moore SA, Soininen S, Haapala EA, Väistö J, Jääskeläinen J, Voutilainen R, Auriola S, Häkkinen MR, Laitinen T, Lakka TA. The Mediating Role of Endocrine Factors in the Positive Relationship Between Fat Mass and Bone Mineral Content in Children Aged 9-11 Years: The Physical Activity and Nutrition in Children Study Front Endocrinol (Lausanne). 2022 Mar 24;13:850448. doi: 10.3389/fendo.2022.850448. eCollection 2022.

Koskivuori J, Voutilainen R, Uusitalo L, Lehtonen M, Lakka T, Auriola S, Häkkinen MR. A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair J Pharm Biomed Anal. 2022 Jun 5;215:114768. doi: 10.1016/j.jpba.2022.114768. Epub 2022 Apr 14.

Lommi S, Manzoor M, Engberg E, Agrawal N, Lakka TA, Leinonen J, Kolho KL, Viljakainen H. The Composition and Functional Capacities of Saliva Microbiota Differ Between Children With Low and High Sweet Treat Consumption Front Nutr. 2022 Apr 25;9:864687. doi: 10.3389/fnut.2022.864687. eCollection 2022.

El-Sayed Moustafa JS, Jackson AU, Brotman SM, Guan L, Villicaña S, Roberts AL, Zito A, Bonnycastle L, Erdos MR, Narisu N, Stringham HM, Welch R, Yan T, Lakka T, ... et al. ACE2 expression in adipose tissue is associated with cardio-metabolic risk factors and cell type composition-implications for COVID-19 Int J Obes (Lond). 2022 Aug;46(8):1478-1486. doi: 10.1038/s41366-022-01136-w. Epub 2022 May 20.

Sallinen T, Viitasalo A, Lintu N, Väistö J, Soininen S, Jalkanen H, Haapala EA, Mikkonen S, Schwab U, Lakka TA, Eloranta AM. The effects of an 8-year individualised lifestyle intervention on food consumption and nutrient intake from childhood to adolescence: the PANIC Study. J Nutr Sci. 2022 Jun 2;11:e40. doi: 10.1017/jns.2022.13. eCollection 2022.

Lima RA, Soares FC, van Poppel M, Savinainen S, Mäntyselkä A, Haapala EA, Lakka T. Determinants of Cognitive Performance in Children and Adolescents: A Populational Longitudinal Study. Int J Environ Res Public Health. 2022 Jul 23;19(15):8955. doi: 10.3390/ijerph19158955.

Virkkala V, Eloranta AM, Suominen AL, Vierola A, Ikävalko T, Väistö J, Mikkonen S, Methuen M, Schwab U, Viljakainen H, Leinonen J, Närhi M, Lakka TA. Associations of diet quality, food consumption, eating frequency, and eating behaviour with dental caries experience in Finnish children: A 2-year longitudinal study. Br J Nutr. 2022 Aug 8:1-31. doi: 10.1017/S0007114522002550. Online ahead of print.

Babu AF, Csader S, Männistö V, Tauriainen MM, Pentikäinen H, Savonen K, Klåvus A, Koistinen V, Hanhineva K, Schwab U.  Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool. Sci Rep. 2022 Apr 20;12(1):6485. doi: 10.1038/s41598-022-10481-9.

Pentikäinen H, Toivo K, Kokko S, Alanko L, Heinonen OJ, Nylander T, Selänne H, Vasankari T, Kujala UM, Villberg J, Parkkari J, Savonen K. Resting Electrocardiogram and Blood Pressure in Young Athletes and Non-Athletes: A 4-year follow-up Clin Physiol Funct Imaging. Clin Physiol Funct Imaging. 2022 May;42(3):200-207. doi: 10.1111/cpf.12747. Epub 2022 Mar 7.

Husu P, Vähä-Ypyä H, Tokola K, Sievänen H, Mänttäri A, Kokko S, Kaikkonen KM, Savonen K, Vasankari T. Measurement of Physical Fitness and 24/7 Physical Activity, Standing, Sedentary Behavior, and Time in Bed in Working-Age Finns: Study Protocol for FINFIT 2021 Methods Protoc. 2022 Jan 13;5(1):7. doi: 10.3390/mps5010007.

Lavikainen P, Mattila E, Absetz P, Harjumaa M, Lindström J, Järvelä-Reijonen E, Aittola K, Männikkö R, Tilles-Tirkkonen T, Lintu N, Lakka T, van Gils M, Pihlajamäki J, Martikainen J. Digitally Supported Lifestyle Intervention to Prevent Type 2 Diabetes Through Healthy Habits: Secondary Analysis of Long-Term User Engagement Trajectories in a Randomized Controlled Trial  J Med Internet Res. 2022 Feb 24;24(2):e31530. doi: 10.2196/31530.

Ronkainen J, Nedelec R, ..., Lakka T, Matthews J, ... et al. LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases  Environ Epidemiol. 2021 Dec 28;6(1):e184. doi: 10.1097/EE9.0000000000000184. eCollection 2022 Feb.

2021

Aittola K, Karhunen L, Männikkö R, ..., Lakka T, et al. Enhanced Eating Competence Is Associated with Improved Diet Quality and Cardiometabolic Profile in Finnish Adults with Increased Risk of Type 2 Diabetes  Nutrients. 2021 Nov 11;13(11):4030. doi: 10.3390

Kuvaja-Köllner V, Lintu N, ..., Lakka TA. Cost-effectiveness of physical activity intervention in children - results based on the Physical Activity and Nutrition in Children (PANIC) study Int J Behav Nutr Phys Act. 2021 Sep 6;18(1):116. doi: 10.1186

Leppänen MH, Haapala EA, Väistö J, Ekelund U, Brage S, Kilpeläinen TO, Lakka TA. Longitudinal and cross-sectional associations of adherence to 24-hour movement guidelines with cardiometabolic risk  Scand J Med Sci Sports. 2022 Jan;32(1):255-266. doi: 10.1111/sms.14081. Epub 2021 Oct 23.

Laukkanen JA, Savonen K, Hupin D, Araújo CGS, Kunutsor SK. Cardiorespiratory optimal point during exercise testing and sudden cardiac death: A prospective cohort study Prog Cardiovasc Dis. 2021 Sep-Oct;68:12-18. doi: 10.1016

Mannarino MR, Bianconi V, Gigante B, Strawbridge RJ, Savonen K, Kurl S, Giral P, Smit A, Eriksson P, Tremoli E, Veglia F, Baldassarre D, Pirro M; IMPROVE study group. Neutrophil to lymphocyte ratio is not related to carotid atherosclerosis progression and cardiovascular events in the primary prevention of cardiovascular disease: Results from the IMPROVE study Biofactors. 2021 Nov 11. doi: 10.1002/biof.1801. Epub 2021 Nov 11.PMID: 34761838

Methuen M, Kauppinen S, ..., Lakka T, Vähänikkilä H, Anttonen V. Dental caries among Finnish teenagers participating in physical activity and diet intervention: association with anthropometrics and behavioural factors  BMC Oral Health. 2021 Jul 6;21(1):333. doi: 10.1186/s12903-021-01690-1.

Constable AM, Porter JE, ..., Lakka TA. The Positive Relationship between Moderate-to-Vigorous Physical Activity and Bone Mineral Content Is Not Mediated by Free Leptin Index in Prepubertal Children: The PANIC Study  Int J Environ Res Public Health. 2021 May 18;18(10):5365. doi: 10.3390/ijerph18105365.

Laukkanen JA, Kunutsor SK, Araújo CG, Savonen K. Cardiorespiratory optimal point during exercise testing is related to cardiovascular and all-cause mortality. Scand J Med Sci Sports. 2021 Oct;31(10):1949-1961. doi: 10.1111. 

Coggi D, Frigerio B, ..., Savonen K, Silveira A, Kurl S, ... et al., on behalf of the Improve Study group. Relationship between Circulating PCSK9 and Markers of Subclinical Atherosclerosis-The IMPROVE Study. Biomedicines 2021;9:841. 

Aira T, Vasankari T, Heinonen OJ,..., Savonen K, et al.. Physical activity from adolescence to young adulthood: patterns of change, and their associations with activity domains and sedentary time. Int J Behav Nutr Phys Act 2021;18:85.

Heikkilä L, Korpelainen R, ..., Savonen K, ..., et al. The associations between adolescents’ sports club participation and dietary habits. Transl Sports Med 2021. https://doi.org/10.1002/

Mannarino MR, Pirro M, Gigante B, Savonen K, ..., et al. IMPROVE Study group. Association between uric acid, carotid intima-media thickness, and cardiovascular events: prospective results from the IMPROVE Study. J Am Heart Assoc.2021 Jun;10(11):e020419.

Husu P, Tokola K,..., Savonen K, Kokko S, Vasankari T. Physical activity, sedentary behavior, and time in bed among Finnish adults measured 24/7 by triaxial accelerometry. JMPB 2021. DOI: 10.3390

Colombo GI, Bianconi V, ..., Savonen KP, Kurl S, ..., et al. IMPROVE Study group. The association between HDL-C and subclinical atherosclerosis depends on CETP plasma concentration: insights from the IMPROVE Study. Biomedicines 2021;9:286.

Laguzzi F, Maitusong B,..., Rauramaa R, ... et al. Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants. Sci Rep. 2021 Apr 12;11(1):7866.

Ji Chen, ..., Lakka TA, ...Rauramaa R, ... et al. The Trans-Ancestral Genomic Architecture of Glycemic Traits. Nat. Gen. 2021. Jun;53(6):840-860..

Wang H, ..., Rauramaa R, ..., Komulainen P, ..., Lakka TA, ..., et al. Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Mol Psychiatry. 2021 Apr 15. doi: 10.1038/s41380-021-01087-0. Online ahead of print.

Komulainen P, Tuomilehto J, Savonen K, Männikkö R, Hassinen M, Lakka TA, Hänninen T, Kiviniemi V, Jacobs Jr DR, Kivipelto M, Rauramaa R. Exercise, diet and cognition in a 4-year randomized controlled trial - DR’s EXTRA. Am J Clin Nutr. 2021 Jun 1;113(6):1428-1439. doi: 10.1093/ajcn/nqab018.

Strawbridge RJ, Johnston KJA, Bailey MES, Baldassarre D, Cullen B, Eriksson P, deFaire U, Ferguson A, Gigante B, Giral P, Graham N, Hamsten A, Humphries SE, Kurl S, Lyall DM, Lyall LM, Pell JP, Pirro M, Savonen K, Smit AJ, Tremoli E, Tomainen TP, Veglia F, Ward J, Sennblad B, Smith DJ. The overlap of genetic susceptibility to schizophrenia and cardiometabolic disease can be used to identify metabolically different groups of individuals. Sci Rep 2021;11:632.

Kolehmainen L, Havulinna S, Ngandu T, Strandberg T, Levälahti E, Lehtisalo J, Antikainen R, Hietikko E, Peltonen M, Pölönen A, Soininen H, Tuomilehto J, Laatikainen T, Rauramaa R, Kivipelto M, Kulmala J. Earlier life leisure-time physical activity in relation to age-related frailty syndrome. Age Ageing. 2021;50:161-168.

Lagou V, …, Rauramaa R, …  et al. Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nat Commun. 2021;12:24.

Haapala EA, Väistö J, Ihalainen JK, González CT, Leppänen MH, Veijalainen A, Sallinen T, Eloranta AM, Ekelund U, Schwab U, Brage S, Atalay M, Lakka TA. Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children. Eur J Sport Sci. 2021:1-25.

Laguzzi F, Baldassarre D, Veglia F, Strawbridge RJ, Humphries SE, Rauramaa R, Smit AJ, Giral P, Silveira A, Tremoli E, Hamsten A, de Faire U, Frumento P, Leander K; IMPROVE Study group. Alcohol consumption in relation to carotid subclinical atherosclerosis and its progression: results from a European longitudinal multicentre study. Eur J Nutr. 2021;60:123-134

Korhonen M, Väistö J, Veijalainen A, Leppänen M, Ekelund U, Laukkanen JA, Brage S, Lintu N, Haapala EA, Lakka TA. Longitudinal associations of physical activity, sedentary time, and cardiorespiratory fitness with arterial health in children - the PANIC study  J Sports Sci. 2021 Apr 8:1-8. doi: 10.1080/02640414.2021.1912450. Online ahead of print.PMID: 33829952

2020

Eloranta AM, Sallinen T, Viitasalo A, Lintu N, Väistö J, Jalkanen H, Tompuri TT, Soininen S, Haapala EA, Kiiskinen S, Schnurr TM, Kilpeläinen TO, Mikkonen S, Savonen K, Atalay M, Brage S, Laaksonen DE, Lindi V, Ågren J, Schwab U, Jääskeläinen J, Lakka TA. The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children: the PANIC Study. Eur J Nutr. 2021;60:425-434.

Jae SY, Heffernan K, Kurl S, Kunutsor SK, Franklin BA, Savonen K, Laukkanen JA. Chronotropic Response to Exercise Testing and the Risk of Stroke. Am J Cardiol. 2021;143:46-50.

Ravi S, Waller B, Valtonen M, Villberg J, Vasankari T, Parkkari J, Heinonen OJ, Alanko L, Savonen K, Vanhala M, Selänne H, Kokko S, Kujala UM. Menstrual dysfunction and body weight dissatisfaction among Finnish young athletes and non-athletes. Scand J Med Sci Sports. 2021;31:405-417.

Joro R, Korkmaz A, Lakka TA, Uusitalo ALT, Atalay M. Plasma irisin and its associations with oxidative stress in athletes suffering from overtraining syndrome. Physiol Int. 2020 Dec 31. In press.

Surendran P, ..., Rauramaa R, …, Lakka TA, …, et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nat. Genet. 2020;52:1314-1332.

Sun D, … Komulainen P, … Lakka TA, ..., Rauramaa R, …, et al. Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits. Human Genetics and Genomics Advances 2020, in press.

Pentikäinen H, Toivo K, Kokko S, Alanko L, Heinonen O, Korpelainen R, Selänne H, Vasankari T,  Kujala U, Villberg J, Parkkari J, Savonen K. Resting electrocardiogram and blood pressure in young endurance and non-endurance athletes and non-athletes. J Athl Train 2021;56:484-490

Kunutsor SK, Mäkikallio TH, Voutilainen A, Blom AW, Savonen K, Laukkanen JA. Cardiorespiratory fitness is not associated with fracture risk in middle-aged men. Eur J Clin Invest 2020;50:e13360.

Toivo K, Kannus P, Kokko S, Alanko L, Heinonen OJ, Korpelainen R, Savonen K, Selänne H, Vasankari T, Kannas L, Kujala UM, Villberg J, Niemelä O, Parkkari J. Haemoglobin, iron status and lung function of adolescents participating in organised sports in the Finnish Health Promoting Sports Club Study. BMJ Open Sport Exerc Med 2020;6:e000804. 

de Las Fuentes L, .., Rauramaa R, …, Komulainen P, …, Lakka TA, … et al. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Mol Psychiatry 2020;10.1038/s41380-020-0719-3.

Lakka TA, Lintu N, Väistö J, Viitasalo A, Sallinen T, Haapala EA, Tompuri TT, Soininen S, Karjalainen P, Schnurr TM, Mikkonen S, Atalay M, Kilpeläinen TO, Laitinen T, Laaksonen DE, Savonen K, Brage S, Schwab U, Jääskeläinen J, Lindi V, Eloranta AM. A 2 year physical activity and dietary intervention attenuates the increase in insulin resistance in a general population of children: the PANIC study. Diabetologia 2020;63:2270-2281. 

Ferri N, Ruscica M, Coggi D, Bonomi A, Amato M, Frigerio B, Sansaro D, Ravani A, Veglia F, Capra N, Lupo MG, Macchi C, Castelnuovo S, Savonen K, Silveira A, Kurl S, Giral P, Pirro M, Strawbridge RJ, Gigante B, Smit AJ, Tremoli E, Colombo GI, Baldassarre D; IMPROVE study group. Sex-specific predictors of PCSK9 levels in a European population: The IMPROVE study. Atherosclerosis. 2020;309:39-46.

Vogelezang S, …, Lakka TA, … et al. Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet. 2020;16:e1008718.

Laukkanen JA, Lakka TA, Ogunjesa BA, Kurl S, Kunutsor SK. Cross-country skiing and the risk of acute myocardial infarction: A prospective cohort study. Eur J Prev Cardiol. 2020;27:1108-1111.

Savinainen SE, Viitasalo A, Sallinen TM, Jääskeläinen JES, Lakka TA. Child-related and parental predictors for thelarche in a general population of girls: the PANIC study. Pediatr Res. 2020;88:676-680.

Bonomi A, Veglia F, Baldassarre D, Strawbridge RJ, Golabkesh Z, Sennblad B, Leander K, Smit AJ, Giral P, Humphries SE, Tremoli E, Hamsten A, de Faire U, Gigante B; on behalf of the IMPROVE study group. Analysis of the genetic variants associated with circulating levels of sgp130. Results from the IMPROVE study. Genes Immun. 2020;21:100-108.

Kunutsor SK, Lakka TA, Kurl S, Mäkikallio TH, Jae SY, Laukkanen JA. Leisure-time cross-country skiing and the risk of venous thromboembolism: A prospective cohort study. Eur J Prev Cardiol. 2020;2:2047487320908978.

Naveed S, Venäläinen T, Eloranta AM, Erkkilä AT, Jalkanen H, Lindi V, Lakka TA, Haapala EA. Associations of dietary carbohydrate and fatty acid intakes with cognition among children. Public Health Nutr. 2020;23:1657-1663.

Leppänen MH, Haapala EA, Veijalainen A, Seppälä S, Oliveira RS, Lintu N, Laitinen T, Tarvainen MP, Lakka TA. Associations of cardiometabolic risk factors with heart rate variability in 6- to 8-year-old children: The PANIC Study. Pediatr Diabetes. 2020;21:251-258.

2019

Sung YJ, ..., Komulainen P, ..., Rauramaa R, ..., Lakka TA, ... et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Hum Mol Genet. 2019;28:2615-2633.

Aira T, Salin K, Vasankari T, Korpelainen R, Parkkari J, Heinonen O, Savonen K, Alanko L, Kannas L, Selänne H, Villberg J, Vähä-Ypyä H, Kokko S. Training volume and intensity of physical activity among young athletes: the Health Promoting Sports Club (HPSC) study. APE 2019;9:270-287.

Tilles-Tirkkonen T, Aittola K, Männikkö R, Absetz P, Kolehmainen M, Schwab U, Lindström J, Lakka T, Pihlajamäki J, Karhunen L. Eating competence is associated with lower prevalence of obesity and better insulin sensitivity in Finnish adults with increased risk for type 2 diabetes: The StopDia Study. Nutrients. 2019;12.

Coley N, Ngandu T, Lehtisalo J, Soininen H, Vellas B, Richard E, Kivipelto M, Andrieu S; HATICE, FINGER, and MAPT/DSA groups. Adherence to multidomain interventions for dementia prevention: Data from the FINGER and MAPT trials. Alzheimers Dement. 2019;15:729-741.

Couto Alves A, …,  Lakka TA, …. et al. GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Sci Adv. 2019;5:eaaw3095.

Veijalainen A, Haapala EA, Väistö J, Leppänen MH, Lintu N, Tompuri T, Seppälä S, Ekelund U, Tarvainen MP, Westgate K, Brage S, Lakka TA. Associations of physical activity, sedentary time, and cardiorespiratory fitness with heart rate variability in 6- to 9-year-old children: the PANIC study. Eur J Appl Physiol. 2019;119:2487-2498.

Noordam R, …, Rauramaa R, …, Komulainen P, …, Lakka TA, … et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nat Commun. 2019;10:5121. 

Viitasalo A, …, Lakka TA, … et al. Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis. Am J Clin Nutr. 2019;110:1079-1087.

Bradfield JP, …, Lakka TA, … et al; Early Growth Genetics Consortium. A Trans-ancestral Meta-Analysis of Genome-Wide Association Studies Reveals Loci Associated with Childhood Obesity. Hum Mol Genet. 2019;28:3327-3338.

Veglia F, Baldassarre D, de Faire U, Kurl S, Smit AJ, Rauramaa R, Giral P, Amato M, Di Minno A, Ravani A, Frigerio B, Castelnuovo S, Sansaro D, Coggi D, Bonomi A, Tedesco CC, Mannarino E, Humphries SE, Hamsten A, Tremoli E; IMPROVE study group. Data on the association between a simplified Mediterranean diet score and the incidence of combined, cardio and cerebro vascular events. Data Brief. 2019;23:103789

Saliba-Gustafsson P, ..., Rauramaa R, ... et al. Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy. J Intern Med. 2019;286:660-675.

Mäntyselkä A, Haapala EA, Lindi V, Häkkinen MR, Auriola S, Jääskeläinen J, Lakka TA. Associations of IGF-1 and adrenal androgens with cognition in childhood. Horm Res Paediatr. 2019;91:329-335.

Viitasalo A, Schnurr TM, Pitkänen N, Hollensted M, Nielsen TRH, Pahkala K, Lintu N, Lind MV, Atalay M, Frithioff-Bøjsøe C, Fonvig CE, Grarup N, Kähönen M, Larnkjaer A, Pedersen O, Holm JC, Michaelsen KF, Lakka TA, Lehtimäki T, Raitakari O, Hansen T, Kilpeläinen TO. Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents. Int J Obes (Lond) 2019;43:2007-2016.

Tompuri TT, Jääskeläinen J, Lindi V, Laaksonen DE, Eloranta AM, Viitasalo A, Laitinen T, Lakka TA. Adiposity criteria in assessing increased cardiometabolic risk in prepubertal children.  Front Endocrinol (Lausanne), 2019;10:410.

Häkkinen MR, Murtola T, Voutilainen R, Poutanen M, Linnanen T, Koskivuori J, Lakka T, Jääskeläinen J, Auriola S. Simultaneous analysis by LC-MS/MS of 22 ketosteroids with hydroxylamine derivatization and underivatized estradiol from human plasma, serum and prostate tissue. J Pharm Biomed Anal. 2019;164:642-652.

Taylor DL, Jackson AU, Narisu N, Hemani G, Erdos MR, Chines PS, Swift A, Idol J, Didion JP, Welch RP, Kinnunen L, Saramies J, Lakka TA, Laakso M, Tuomilehto J, Parker SCJ, Koistinen HA, Davey Smith G, Boehnke M, Scott LJ, Birney E, Collins FS. Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle. Proc Natl Acad Sci U S A. 2019;116:10883-10888.

Warrington NM, ..., Lakka TA, ... et al. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat Genet. 2019;51:804-814.

Säisänen L, Määttä S, Julkunen P, Niskanen E, Kallioniemi E, Gröhn H, Kemppainen S, Lakka TA, Lintu N, Eloranta AM, Vanninen R, Makkonen I, Könönen M.  Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study. Brain Topogr. 2019;32:504-518.

Bentley AR, ..., Komulainen P, ..., Rauramaa R, ..., Lakka TA, ... et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nat Genet. 2019;51:636-648.

Pihlajamäki J, Männikkö R, Tilles-Tirkkonen T, Karhunen L, Kolehmainen M, Schwab U, Lintu N, Paananen J, Järvenpää R, Harjumaa M, Martikainen J, Kohl J, Poutanen K, Ermes M, Absetz P, Lindström J, Lakka TA; StopDia study group. Digitally supported program for type 2 diabetes risk identification and risk reduction in real-world setting: protocol for the StopDia model and randomized controlled trial. BMC Public Health. 2019;19:255.

Kulmala J, Ngandu T, Havulinna S, Levälahti E, Lehtisalo J, Solomon A, Antikainen R, Laatikainen T, Pippola P, Peltonen M, Rauramaa R, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M. The effect of multidomain lifestyle intervention on daily functioning in older people. J Am Geriatr Soc. 2019;67:1138-1144.

Ristolainen L, Toivo K, Parkkari J, Kokko S, Alanko L, Heinonen OJ, Korpelainen R, Savonen K, Selänne H, Vasankari T, Kannas L, Villberg J, Kujala UM. Acute and overuse injuries among sports club members and non-members: the Finnish Health Promoting Sports Club (FHPSC) study. BMC Musculoskelet Disord. 2019;20:32.

Pentikäinen H, Savonen K, Ngandu T, Solomon A, Komulainen P, Paajanen T, Antikainen R, Kivipelto M, Soininen H, Rauramaa R. Cardiorespiratory fitness and cognition: longitudinal associations in the FINGER Study. J Alzheimers Dis. 2019;68:961-968.

Justice AE,… Komulainen P,...,Lakka TA,…,Rauramaa R,…,et al. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nat Genet. 2019;51:452-469.

de Vries PS, …,Komulainen P,…, Lakka TA,…, Rauramaa R,…et al. Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions. Am J Epidemiol 2019;188:1033-1054.

Kivipelto M, Kulmala J, Lehtisalo J, Solomon A, Lindström J, Rauramaa R, Peltonen M, Laatikainen T, Havulinna S, Soininen H, Tuomilehto J, Hänninen T, Paajanen T, Antikainen R, Strandberg T, Ngandu T. FINGER-elintapaohjelma - toimintamalli kognitiivisen toimintakyvyn tukemiseen. Lääkärilehti 2019;74:183-6.

Kilpeläinen TO, … Komulainen P, … Lakka TA, ... Rauramaa R, ...et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nat Commun 2019;10:376.

Agbaje AO, Haapala EA, Lintu N, Viitasalo A, Väistö J, Khan S, Veijalainen A, Tompuri T, Laitinen T, Lakka TA. Associations of cardiorespiratory fitness and adiposity with arterial stiffness and arterial dilatation capacity in response to a bout of exercise in children. Pediatr Exerc Sci 2019;31:238-247.

Määttä S, Säisänen L, Kallioniemi E, Lakka TA, Lintu N, Haapala EA, Koskenkorva P, Niskanen E, Ferreri F, Könönen M. Maturation changes the excitability and effective connectivity of the frontal lobe: A developmental TMS-EEG study. Hum Brain Mapp. 2019;40:2320-2335.

Väistö J, Haapala EA, Viitasalo A, Schnurr TM, Kilpeläinen TO, Karjalainen P, Westgate K, Lakka HM, Laaksonen DE, Ekelund U, Brage S, Lakka TA. Longitudinal associations of physical activity and sedentary time with cardiometabolic risk factors in children. Scand J Med Sci Sports 2019;29:113-123.

Agbaje AO, Haapala EA, Lintu N, Viitasalo A, Barker AR, Takken T, Tompuri T, Lindi V, Lakka TA. Peak oxygen uptake cut-points to identify children at increased cardiometabolic risk - The PANIC Study. Scand J Med Sci Sports 2019;29:16-24.

Haapala EA, Lintu N, Väistö J, Tompuri T, Soininen S, Viitasalo A, Eloranta AM, Venäläinen T, Sääkslahti A, Laitinen T, Lakka TA. Longitudinal associations of fitness, motor competence, and adiposity with cognition. Med Sci Sports Exerc 2019;51:465-471.

Veglia F, ..., Rauramaa R, ..., et al.; IMPROVE study group. A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries. Int J Cardiol 2019;282:88-92.

2018

Warrington NM, …, Lakka T, et al. Maternal and fetal genetic contribution to gestational weight gain. Int. J. Obes. 2018;42:775-784.

Schnurr TM, Viitasalo A, Eloranta A-M, Damsgaard CT, Mahendran Y, Have CT, Väistö J, Hjorth MF, Christensen LB, Brage S, Atalay M, Lyytikainen L-P, Lindi V, Lakka T, Michaelsen KF, Kilpelainen TO, Hansen T. Genetic predisposition to adiposity is associated with increased objectively assessed sedentary time in young children. Int J. Obes. 2018;42:111-114.

Ikävalko T, Närhi M, Eloranta A-M, Lintu N, Myllykangas R, Vierola A, Tuomilehto H, Lakka T, Pahkala R. Predictors of sleep disordered breathing in children: the PANIC study. Eur. J. Orthod. 2018;40:268-272.

Säisänen L, Julkunen P, Lakka T, Lindi V, Könönen M, Määttä S. Development of corticospinal motor excitability and cortical silent period from mid-childhood to adulthood – a navigated TMS study. Neurophysiol Clin 2018;48:65-75.

Häkkinen MR, Heinosalo T, Saarinen N, Linnanen T, Voutilainen R, Lakka T, Jääskeläinen J, Poutanen M, Auriola S. Analysis by LC-MS/MS of endogenous steroids from human serum, plasma, endometrium and endometriotic tissue. J Pharm Biomed Anal. 2018;152:165-172.

Haworth S, …, Lakka T, …, et al. Consortium-based genome-wide meta-analysis for childhood dental caries traits. Hum Mol Genet. 2018;27:3113-3127.

Khan H, Kella D, Kunutsor SK, Savonen K, Laukkanen JA. Sleep duration and risk of fatal coronary heart disease, sudden cardiac death, cancer death, and all-cause mortality. Am J Med 2018;131:1499-1505. 

Toivo K, Kannus P, Kokko S, Alanko L, Heinonen OJ, Korpelainen R, Savonen K, Selänne H, Vasankari T, Kannas L, Kujala UM, Villberg J, Parkkari J. Musculoskeletal examination in young athletes and non-athletes: the Finnish Health Promoting Sports Club (FHPSC) study. BMJ Open Sport Exerc Med 2018;4(1):e000376.

Franceschini N, …, Rauramaa R, …, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun 2018;9:5141.

Penttilä I, Laitinen H, Ranta P, Penttilä K, Törrönen J, Rauramaa R. HbA1c-analytiikka ja määritysmenetelmien laatu laaduntarkkailutulosten valossa. Kliin Lab 2018;34:132-139.

Haapala EA, Lintu N, Eloranta AM, Venäläinen T, Poikkeus AM, Ahonen T, Lindi V, Lakka TA. Mediating effects of motor performance, cardiorespiratory fitness, physical activity, and sedentary behaviour on the associations of adiposity and other cardiometabolic risk factors with academic achievement in children. J Sports Sci 2018;36:2296-2303.

Haapala EA, Paananen J, Hiltunen M, Lakka TA. Associations of genetic susceptibility to alzheimer's disease with adiposity and cardiometabolic risk factors among children in a 2-year follow-up study. J Alzheimers Dis 2018;64:587-595.

Feitosa MF, …, Komulainen P, …, Rauramaa R, …, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS One 2018;13:e0198166.

Mäntyselkä A, Lindi V, Viitasalo A, Eloranta AM, Ågren J, Väisänen S, Voutilainen R, Laitinen T, Lakka TA, Jääskeläinen J. Associations of dehydroepiandrosterone sulfate with cardiometabolic risk factors in prepubertal children. J Clin Endocrinol Metab 2018;103:2592-2600.

Soininen S, Eloranta AM, Viitasalo A, Dion G, Erkkilä A, Sidoroff V, Lindi V, Mahonen A, Lakka TA. Serum 25-hydroxyvitamin D, plasma lipids, and associated gene variants in prepubertal children. J Clin Endocrinol Metab 2018;103:2670-2679.

Taylor DL, Knowles DA, Scott LJ, Ramirez AH, Casale FP, Wolford BN, Guan L, Varshney A, Albanus RD, Parker SCJ, Narisu N, Chines PS, Erdos MR, Welch RP, Kinnunen L, Saramies J, Sundvall J, Lakka TA, Laakso M, Tuomilehto J, Koistinen HA, Stegle O, Boehnke M, Birney E, Collins FS. Interactions between genetic variation and cellular environment in skeletal muscle gene expression. PLoS One 2018;13:e0195788.

Ikävalko T, Lehto S, Lintu N, Väistö J, Eloranta AM, Haapala EA, Vierola A, Myllykangas R, Tuomilehto H, Brage S, Pahkala R, Närhi M, Lakka TA. Health-related correlates of psychological well-being among girls and boys 6-8 years of age: The Physical Activity and Nutrition in Children study. J Paediatr Child Health 2018;54:506-509.

Soininen S, Sidoroff V, Lindi V, Mahonen A, Kröger L, Kröger H, Jääskeläinen J, Atalay M, Laaksonen DE, Laitinen T, Lakka TA. Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6-8years of age - The Physical Activity and Nutrition in Children (PANIC) study. Bone 2018;108:106-114.

Medina-Gomez C, …, Lakka TA, …, Rivadeneira F et al. Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. Am J Hum Genet 2018;102:88-102.

Mäntyselkä A, Jääskeläinen J, Eloranta AM, Väistö J, Voutilainen R, Ong K, Brage S, Lakka TA, Lindi V. Associations of lifestyle factors with serum dehydroepiandrosterone sulphate and insulin-like growth factor-1 concentration in prepubertal children. Clin Endocrinol (Oxf) 2018;88:234-242.

Mahajan A, …, Rauramaa R, … et al. Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nat Genet 2018;50:559-571.

Khan H, Kunutsor SK, Rauramaa R, Merchant FM, Laukkanen JA. Long-term change in cardiorespiratory fitness in relation to atrial fibrillation and heart failure (from the Kuopio Ischemic Heart Disease Risk Factor Study). Am J Cardiol 2018;121:956-960.

Tedesco CC, Veglia F, de Faire U, Kurl S, Smit AJ, Rauramaa R, Giral P, Amato M, Bonomi A, Ravani A, Frigerio B, Castelnuovo S, Sansaro D, Mannarino E, Humphries SE, Hamsten A, Tremoli E, Baldassarre D; IMPROVE study group. Association of lifelong occupation and educational level with subclinical atherosclerosis in different European regions. Results from the IMPROVE study. Atherosclerosis 2018;269:129-137.

Kamleh MA, McLeod O, Checa A, Baldassarre D, Veglia F, Gertow K, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Tremoli E, Silveira A, Örvik J, Hamsten A. Wheelock CE. Increased levels of circulating fatty acids are associated with protective effects against future cardiovascular events in nondiabetics. J Proteome Res 2018;17:870-878.

Sung YJ, …, Rauramaa R, …, Komulainen P, …, et. al. A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. Am J Hum Genet 2018;102:375-400.

Turcot V, …, Komulainen P, …, Lakka TA, …, Rauramaa R, … et.al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet 2018;50:26-41. 

Hagnäs MJ, Lakka TA, Mäkikallio TH, Kurl S, Savonen K, Rauramaa R, Laukkanen JA. High leisure-time physical activity is associated with reduced risk of sudden cardiac death among men with low cardiorespiratory fitness. Can J Cardiol 2018;34:288-294.

Tajik B, Kurl S, Tuomainen TP, Savonen K, Virtanen JK. Associations of the serum long-chain n-3 PUFA and hair mercury with resting heart rate, peak heart rate during exercise and heart rate recovery after exercise in middle-aged men. Br J Nutr 2018;119:66-73.

Tompuri T, Lintu N, Laitinen T, Lakka TA. Relation of oxygen uptake to work rate in prepubertal healthy children - reference for VO2/W-slope and effect on cardiorespiratory fitness assessment. Clin Physiol Funct Imaging 2018;38:645-651.

2017 

Graff M, …, Komulainen P, …, Savonen K, …, Lakka TA, ..., Rauramaa R, … et.al. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet 2017;13:e1006528.

Justice AE, …, Komulainen P, ..., Lakka TA, ..., Savonen K, ..., Rauramaa R, ... et. al. Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 2017;8:14977. 

Marouli E, …, Komulainen P, ..., Lakka TA, ..., Rauramaa R,  … et al. Rare and low-frequency coding variants alter human adult height. Nature 2017;542:186-190.

Pentikäinen H, Savonen K, Komulainen P, Kiviniemi V, Paajanen T, Kivipelto M, Soininen H, Rauramaa R. Muscle strength and cognition in ageing men and women: The DR’s EXTRA study. Eur Geriatr Med 2017;8:275-277.

HPS3/TIMI55–REVEAL Collaborative Group, Bowman L, …, Savonen K, …, Landray MJ et al. Effects of Anacetrapib in patients with atherosclerotic vascular disease. N Engl J Med 2017;377:1217-27.

Hinney A, …, Rauramaa R, ... et al. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry 2017;22:192-201.

Khan H, Jaffar N, Rauramaa R, Kurl S, Savonen K, Laukkanen JA. Cardiorespiratory fitness and nonfatalcardiovascular events: A population-based follow-up study. Am Heart J 2017;184:55-61. 

Flannick J, …, Rauramaa R, … et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Sci Data 2017;4:170179.

Liu DJ, …, Lakka T, ..., Rauramaa R, … et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nat Genet 2017;49:1758-1766. 

Strawbridge RJ, ..., Rauramaa R, ..., et al.; IMPROVE study group. Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. Atherosclerosis 2017;266:196-204.

Kraja AT, …, Rauramaa R, …, Lakka TA, … et al, CHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia, The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group†. New blood pressure-associated loci identified in meta-analyses of 475 000 individuals. Circ Cardiovasc Genet 2017;10:e001778.

Kunutsor SK, Kurl S, Khan H, Zaccardi F, Rauramaa R, Laukkanen JA. Oxygen uptake at aerobic threshold is inversely associated with fatal cardiovascular and all-cause mortality events. Ann Med 2017;49:698-709.

Penttilä I. Huume- ja dopingongelmat meillä ja muualla. Kliin Lab 2017;34:99-100.

Amato M, Veglia F, de Faire U, Giral P, Rauramaa R, Smit AJ, Kurl S, Ravani A, Frigerio B, Sansaro D, Bonomi A, Tedesco CC, Castelnuovo S, Mannarino E, Humphries SE, Hamsten A, Tremoli E, Baldassarre D; IMPROVE study group. Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification. Atherosclerosis 2017;263:412-419.

Folkersen L, Fauman E, Sabater-Lleal M, Strawbridge RJ, Frånberg M, Sennblad B, Baldassarre D, Veglia F, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Enroth S, Johansson Å, Enroth SB, Gustafsson S, Lind L, Lindgren C, Morris AP, Giedraitis V, Silveira A, Franco-Cereceda A, Tremoli E; IMPROVE study group, Gyllensten U, Ingelsson E, Brunak S, Eriksson P, Ziemek D, Hamsten A, Mälarstig A. Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease. PLoS Genet 2017;13:e1006706.

Penttilä I, Eklund S, Väisänen S. Lipidimääritysten laatu ja käytettävyys Labquality Oy:n 23 vuoden laadunarviointikierrosten pohjalta. Kliin Lab 2017;34:108-114.

Manning A, …, Lakka TA, ..., Rauramaa R, … et al. A low-frequency inactivating AKT2 variant enriched in the finnish population Is associated with fasting insulin levels and type 2 diabetes risk. Diabetes 2017;66:2019-2032.

Vierola A, Suominen AL, Eloranta AM, Lintu N, Ikävalko T, Närhi M, Lakka TA. Determinants for craniofacial pains in children 6-8 years of age: the PANIC study. Acta Odontol Scand 2017;75:453-460.

Penttilä I. HbA1c analytiikan tilanne meillä ja muualla diabetestutkimuksena. Moodi 2017;2:40-42.

Jalkanen H, Lindi V, Schwab U, Kiiskinen S, Venäläinen T, Karhunen L, Lakka TA, Eloranta AM. Eating behaviour is associated with eating frequency and food consumption in 6-8 year-old children: The Physical Activity and Nutrition in Children (PANIC) study. Appetite 2017;114:28-37.

Lampinen EK, Eloranta AM, Haapala EA, Lindi V, Väistö J, Lintu N, Karjalainen P, Kukkonen-Harjula K, Laaksonen D, Lakka TA. Physical activity, sedentary behaviour, and socioeconomic status among Finnish girls and boys aged 6-8 years. Eur J Sport Sci 2017;17:462-472.

Haapala EA, Väistö J, Lintu N, Westgate K, Ekelund U, Poikkeus AM, Brage S, Lakka TA. Physical activity and sedentary time in relation to academic achievement in children. J Sci Med Sport 2017;20:583-589.

Haapala EA, Eloranta AM, Venäläinen T, Jalkanen H, Poikkeus AM, Ahonen T, Lindi V, Lakka TA. Diet quality and academic achievement: a prospective study among primary school children. Eur J Nutr 2017;56:2299-2308.

Collings PJ, Westgate K, Väistö J, Wijndaele K, Atkin AJ, Haapala EA, Lintu N, Laitinen T, Ekelund U, Brage S, Lakka TA. Cross-sectional associations of objectively-measured physical activity and sedentary time with body composition and cardiorespiratory fitness in mid-childhood: The PANIC Study. Sports Med 2017;47:769-780.

Hagnäs MJ, Lakka TA, Kurl S, Rauramaa R, Mäkikallio TH, Savonen K, Laukkanen JA. Cardiorespiratory fitness and exercise-induced ST segment depression in assessing the risk of sudden cardiac death in men. Heart 2017;103:383-389.

Pentikäinen H, Ngandu T, Liu Y, Savonen K, Komulainen P, Hallikainen M, Kivipelto M, Rauramaa R, Soininen H. Cardiorespiratory fitness and brain volumes in men and women in the FINGER study. Age Ageing 2017;46:310-313.

2016

Viitasalo A, Eloranta AM, Atalay M, Romeo S, Pihlajamäki J, Lakka TA. Association of MBOAT7 gene variant with plasma ALT levels in children: the PANIC study. Pediatr Res 2016;80(5):651-655.

Eloranta AM, Venäläinen T, Soininen S, Jalkanen H, Kiiskinen S, Schwab U, Lakka TA, Lindi V. Food sources of energy and nutrients in Finnish girls and boys 6-8 years of age - the PANIC study. Food Nutr Res 2016;60:32444.

Horikoshi M, …, Lakka TA, …, et al. Genome-wide associations for birth weight and correlations with adult disease. Nature 2016;538(7624):248-252.

Haapala EA, Viitasalo A, Venäläinen T, Eloranta AM, Ågren J, Lindi V, Lakka TA. Plasma polyunsaturated fatty acids are directly associated with cognition in overweight children but not in normal weight children. Acta Paediatr 2016;105(12):1502-1507.

Venäläinen TM, Viitasalo AM, Schwab US, Eloranta AM, Haapala EA, Jalkanen HP, de Mello VD, Laaksonen DE, Lindi VI, Ågren JJ, Lakka TA. Effect of a 2-y dietary and physical activity intervention on plasma fatty acid composition and estimated desaturase and elongase activities in children: the Physical Activity and Nutrition in Children Study. Am J Clin Nutr 2016;104(4):964-972.

Eloranta AM, Schwab U, Venäläinen T, Kiiskinen S, Lakka HM, Laaksonen DE, Lakka TA, Lindi V. Dietary quality indices in relation to cardiometabolic risk among Finnish children aged 6-8 years - The PANIC study. Nutr Metab Cardiovasc Dis 2016;26(9):833-41.

Scott LJ, ..., Lakka TA, ..., et al. The genetic regulatory signature of type 2 diabetes in human skeletal muscle. Nat Commun 2016;7:11764.

Vierola A, Suominen AL, Lindi V, Viitasalo A, Ikävalko T, Lintu N, Väistö J, Kellokoski J, Närhi M, Lakka TA. Associations of sedentary behavior, physical activity, cardiorespiratory fitness, and body fat content with pain conditions in children: The Physical Activity and Nutrition in Children Study. J Pain 2016;17(7):845-53.

Viitasalo A, Eloranta AM, Lintu N, Väistö J, Venäläinen T, Kiiskinen S, Karjalainen P, Peltola J, Lampinen EK, Haapala EA, Paananen J, Schwab U, Lindi V, Lakka TA. The effects of a 2-year individualized and family-based lifestyle intervention on physical activity, sedentary behavior and diet in children. Prev Med 2016;87:81-88.

Venäläinen T, Ågren J, Schwab U, de Mello VD, Eloranta AM, Laaksonen DE, Lindi V, Lakka TA. Cross-sectional associations of plasma fatty acid composition and estimated desaturase and elongase activities with cardiometabolic risk in Finnish children -The PANIC study. J Clin Lipidol 2016;10(1):82-91.

Viitasalo A, Pihlajamäki J, Paananen J, Atalay M, Lindi V, Lakka TA. Associations of TM6SF2 167K allele with liver enzymes and lipid profile in children: the PANIC Study. Pediatr Res 2016;79(5):684-8.

Haapala EA, Väistö J, Lintu N, Tompuri T, Brage S, Westgate K, Ekelund U, Lampinen EK, Sääkslahti A, Lindi V, Lakka TA. Adiposity, physical activity and neuromuscular performance in children. J Sports Sci 2016;34(18):1699-706.

Felix JF, …, Lakka TA, …, et al. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet 2016;25(2):389-403.

Viitasalo A, Ågren J, Venäläinen T, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Atalay M, Lakka TA. Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children. Pediatr Obes 2016;11(4):299-305.

Veijalainen A, Tompuri T, Haapala EA, Viitasalo A, Lintu N, Väistö J, Laitinen T, Lindi V, Lakka TA. Scand J. Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children. Scand J Med Sci Sports 2016;26(8):943-50.

Ried JS, …, Rauramaa R, ... et al. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat Commun 2016;23;7:13357.

Kulmala J, Ngandu T, Pajala S, Lehtisalo J, Levälahti E, Antikainen R, Laatikainen T, Oksa H, Peltonen M, Rauramaa R, Soininen H, Strandberg T, Tuomilehto J, Kivipelto M. Leisure-time and occupational physical activity in early and late adulthood in relation to later life physical functioning. J Phys Act Health 2016;13:1079-1087.

Strawbridge RJ, …, Rauramaa R, ... et al. IMPROVE Study Group. Soluble CD93 Is Involved in metabolic dysregulation but does not Influence carotid intima-media thickness. Diabetes 2016;65:2888-99.

Ehret GB, …, Rauramaa R, ..., Komulainen P, ... et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.  Nat Genet 2016;48:1171-84.

Surendran P, … Rauramaa R, Komulainen P, ... et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet 2016;48:1151-61.  

Rossi M, Pasanen K, Kokko S, Alanko L, Heinonen OJ, Korpelainen R, Savonen K, Selänne H, Vasankari T, Kannas L, Kujala U, Villberg J, Parkkari J. Low back and neck and shoulder pain in members and non-members of adolescents' sports clubs: The Finnish Health Promoting Sports Club (FHPSC) Study. BMC Musculoskelet Disord 2016;17:263.

Lintu N, Savonen K, Viitasalo A, Tompuri T, Paananen J, Tarvainen MP, Lakka T. Determinants of cardiorespiratory fitness in a population sample of girls and boys aged 6-8 years. J Phys Act Health 2016 ;13:1149-1155. 

Laukkanen JA, Zaccardi F, Khan H, Kurl S, Jae SY, Rauramaa R. Long-term change in cardiorespiratory fitness and all-cause mortality: A population-based follow-up study. Mayo Clin Proc 2016;91:1183-8.

Fuchsberger C, …, Rauramaa R, ... et al. The genetic architecture of type 2 diabetes.Nature 2016;536:41-7.

Mäkelä K, Kokko S, Kannas L, Vasankari T, Heinonen OJ, Savonen K, Alanko L, Korpelainen R, Selänne H, Villberg J, Parkkari J. Physical activity, screen time and sleep among youth participating and non-participating in organized sports - The Finnish Health Promoting Sports Club (FHPSC) Study. APE 2016;6:378-88.                         

Zanoni P, …, Rauramaa R, ..., Komulainen P, ... et al. Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science 2016;351:1166-71.

Pletnikoff PP, Tuomainen TP, Laukkanen JA, Kauhanen J, Rauramaa R, Ronkainen K, Kurl S. Cardiorespiratory fitness and lung cancer risk: A prospective population-based cohort study. J Sci Med Sport 2016;19:98-102.

Rankinen T, …, Rauramaa R, ... et al. No evidence of a common dna variant profile specific to world class endurance athletes. PLoS One 2016;11(1):e0147330.

2015

Winkler TW, …, Lakka TA, …, Rauramaa R, ... et al. The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study. PLoS Genet. 2015;11:e1005378.

Haapala EA, Lintu N, Väistö J, Robinson LE, Viitasalo A, Lindi V, Lakka TA. Associations of physical performance and adiposity with cognition in children. Med Sci Sports Exerc 2015;47(10):2166-74.

Qi Q, ..., Lakka TA, ... et al. Dietary Intake, FTO Genetic Variants, and Adiposity: A combined analysis of over 16,000 children and adolescents. Diabetes 2015;64(7):2467-76.

Viitasalo A, Atalay M, Pihlajamäki J, Jääskeläinen J, Korkmaz A, Kaminska D, Lindi V, Lakka TA. The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study. Metabolism 2015;64(7):793-6.

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka TA. Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: The PANIC Study. Pediatr Obes 2015;10(2):84-90.

Gaulton KJ, …, Lakka TA, Rauramaa R, Komulainen P, ... et al. DIAbetes genetics replication and meta-analysis (DIAGRAM) consortium. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet 2015;47:1415-25.

Krachler B, Savonen K, Lakka T. Obesity is an important source of bias in the assessment of cardiorespiratory fitness. Am Heart J 2015;170:e7-8.

Tompuri T, Lintu N, Savonen K, Laitinen T, Laaksonen D, Jääskeläinen J, Lakka TA. Measures of cardiorespiratory fitness in relation to measures of body size and composition among children. Clin Physiol Funct Imaging 2015;35:469-77.

Hagnäs MJ, Kurl S, Rauramaa R, Lakka TA, Mäkikallio TH, Savonen K, Laukkanen JA. The value of cardiorespiratory fitness and exercise-induced ST segment depression in predicting death from coronary heart disease. Int J Cardiol 2015;196:31-3.

Krachler B, Savonen K, Komulainen P, Hassinen M, Lakka TA, Rauramaa R. Cardiopulmonary fitness is a function of lean mass, not total body weight: The DR’s EXTRA Study. Eur J Prev Cardiol. 2015;22:1171-79.

Penttilä I, Penttilä K, Holm P, Laitinen H, Rauramaa R. Hemoglobin A1c reported in units and diagnostic cut-offs in relation to the international recommendations. Clin Chem Lab Med 2015;53:e215-7.

Persson J, ..., Rauramaa R, et al. IMPROVE Study Group. Sex-specific effects of adiponectin on carotid intima-media thickness and incident cardiovascular disease. J Am Heart Assoc 2015;4(8):e001853.

Pletnikoff PP, Laukkanen JA, Tuomainen TP, Kauhanen J, Rauramaa R, Ronkainen K, Kurl S. Cardiorespiratory fitness, C-reactive protein and lung cancer risk: A prospective population-based cohort study. Eur J Cancer 2015;51:1365-70.

Khan H, Kella D, Rauramaa R, Savonen K, Lloyd MS, Laukkanen JA. Cardiorespiratory fitness and atrial fibrillation: A population-based follow-up study. Heart Rhythm 2015;12:1424-30.

Männikkö R, Komulainen P, Schwab U, Heikkilä HM, Savonen K, Hassinen M, Hänninen T, Kivipelto M, Rauramaa R. The Nordic diet and cognition - The DR’s EXTRA Study. Br J Nutr 2015;24:1-9.

Ngandu T, Lehtisalo J, Solomon A, Levälahti E, Ahtiluoto S, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial. Lancet 2015;385:2255-63.

Silveira A, McLeod O, Strawbridge RJ, Gertow K, Sennblad B, Baldassarre D, Veglia F, Deleskog A, Persson J, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Gustafsson S, Söderberg S, Öhrvik J, Humphries SE, Tremoli E, de Faire U, Hamsten A. Plasma IL-5 concentration and subclinical carotid atherosclerosis. Atherosclerosis 2015;239:125-30.

Locke AE, Kahali B, Berndt SI, … Rauramaa R, … Komulainen P, ... et al. Genetic studies of body mass index yield new insights for obesity biology. Nature 2015;518:197-206.

Shungin D, Winkler TW, Croteau-Chonka DC, … Rauramaa R, … Komulainen P, ... et al. New genetic loci link adipose and insulin biology to body fat distribution. Nature 2015;518:187-96.

Rahmioglu N, Macgregor S, Drong AW,… GIANT Consortium,… et al. Genome-wide enrichment analysis between endometriosis and obesity-related traits reveals novel susceptibility loci. Hum Mol Genet 2015;24:1185-99.

Kurl S, Jae SY, Kauhanen J, Ronkainen K, Rauramaa R, Laukkanen JA. Exercise cardiac power and the risk of sudden cardiac death in a long-term prospective study. Int J Cardiol 2015;181:155-9.

Lintu N, Viitasalo A, Tompuri T, Veijalainen A, Hakulinen M, Laitinen T, Savonen K, Lakka TA. Cardiorespiratory fitness, respiratory function and hemodynamic responses to maximal cycle ergometer exercise test in girls and boys aged 9-11 years: the PANIC Study. Eur J Appl Physiol 2015;115:235-43.

Kokko S,  Selänne H, Alanko L, Heinonen OJ, Korpelainen R, Savonen K, Vasankari T, Kannas L, Kujala UM, Aira T, Villberg J, Parkkari J. Health promotion activities of sports clubs and coaches, and health and health behaviours in youth participating in sports clubs: The Health Promoting Sports Club Study. BMJ Open Sport Exerc Med 2015;1(1):e00003 .

Pers TH, …, Rauramaa R, … et al. Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun 2015;6:5890.

Mahajan A, Sim X, Ng HJ, …Rauramaa R, … et al. Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. PLoS Genet 2015;11:e1004876 .

Hakola L, Savonen K, Komulainen P, Hassinen M, Rauramaa R, Lakka T. Moderators of maintained increase in aerobic exercise among aging men and women in a 4-year randomized controlled trial: The DR's EXTRA Study. J Phys Act Health 2015;12:1477-84.

Hakola L, Hassinen M, Komulainen P, Lakka TA, Savonen K, Rauramaa R. Correlates of low physical activity levels in aging men and women: The DR's EXTRA Study. J Aging Phys Act 2015;23:247-55.

2014

Haapala EA, Poikkeus AM, Kukkonen-Harjula K, Tompuri T, Lintu N, Väistö J, Leppänen PH, Laaksonen DE, Lindi V, Lakka TA. Associations of physical activity and sedentary behavior with academic skills--a follow-up study among primary school children. PLoS One 2014;9(9):e107031.

Haapala EA, Poikkeus AM, Tompuri T, Kukkonen-Harjula K, Leppänen PH, Lindi V, Lakka TA. Associations of motor and cardiovascular performance with academic skills in children. Med Sci Sports Exerc 2014;46(5):1016-24.

Mäntyselkä A, Jääskeläinen J, Lindi V, Viitasalo A, Tompuri T, Voutilainen R, Lakka TA. The presentation of adrenarche is sexually dimorphic and modified by body adiposity. J Clin Endocrinol Metab 2014;99(10):3889-94.

Silveira A, McLeod O, Strawbridge RJ, Gertow K, Sennblad B, Baldassarre D, Veglia F, Deleskog A, Persson J, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Gustafsson S, Söderberg S, Öhrvik J, Humphries SE, Tremoli E, de Faire U, Hamsten A. Plasma IL-5 concentration and subclinical carotid atherosclerosis. Atherosclerosis 2014;239:125-130.

Kurl S, Jae SY, Kauhanen J, Ronkainen K, Rauramaa R, Laukkanen JA. Exercise cardiac power and the risk of sudden cardiac death in a long-term prospective study. Int J Cardiol 2014;181C:155-159.

Wood AR, …, Hassinen M, …, Lakka TA, …, Rauramaa R, ... et al. Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet 2014;46:1173-86.

Heikkilä HM, Krachler B, Rauramaa R, Schwab US. Diet, insulin secretion and insulin sensitivity - the Dose-Responses to Exercise Training (DR's EXTRA) Study. Br J Nutr 2014;112(9):1530-41.

Ngandu T, Lehtisalo J, Levälahti E, Laatikainen T, Lindström J, Peltonen M, Solomon A, Ahtiluoto S, Antikainen R, Hänninen T, Jula A, Mangialasche F, Paajanen T, Pajala S, Rauramaa R, Strandberg T, Tuomilehto J, Soininen H, Kivipelto M. Recruitment and baseline characteristics of participants in the finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER) - A randomized controlled lifestyle trial. Int J Environ Res Public Health 2014;11(9):9345-60.

Gigante B, Leander K, Vikström M, Baldassarre D, Veglia F, Strawbridge RJ, McLeod O, Gertow K, Sennblad B, Shah S, Zabaneh D, Humphries SE, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Tremoli E, Hamsten A, Frostegård J, de Faire U; IMPROVE Study Group. Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men. Atherosclerosis 2014;236:394-9.

Winkler TW, Day FR, Croteau-Chonka DC,.. Rauramaa R, ... et al. Genetic Investigation of Anthropometric Traits (GIANT) Consortium. Quality control and conduct of genome-wide association meta-analyses. Nat Protoc 2014;9:1192-212.

Hoggart CJ, … Rauramaa R, … et al. Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. PLoS Genet 2014;10(4):e1004508.

Seppälä S, Laitinen T, Tarvainen MP, Tompuri T, Veijalainen A, Savonen K, Lakka T. Normal values for heart rate variability parameters in children 6-8 years of age: the PANIC Study. Clin Physiol Funct Imaging 2014;34:290-6.

Strawbridge RJ, Deleskog A, McLeod O,… Rauramaa R, ... et al. A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness). Diabetologia 2014;57:1159-72.

Viitasalo A, Lakka TA, Laaksonen DE, Savonen K, Lakka HM, Hassinen M, Komulainen P, Tompuri T, Kurl S, Laukkanen JA, Rauramaa R. Validation of metabolic syndrome score by confirmatory factor analysis in children and adults and prediction of cardiometabolic outcomes in adults. Diabetologia 2014;57:940-9.

Prokopenko I, …, Lakka TA, …, Rauramaa R, …. et al. A central role for GRB10 in regulation of islet function in man. PLoS Genet 2014;10. e1004235.

Flannick J, …, Rauramaa R, … et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat Genet 2014;46:357-63.

DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, …, Mahajan A, …, Lakka TA, …, Rauramaa R, … et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 2014;46:234-44.

Lintu N, Tompuri T, Viitasalo A, Soininen S, Laitinen T, Savonen K, Lindi V, Lakka TA. Cardiovascular fitness and haemodynamic responses to maximal cycle ergometer exercise test in children 6-8 years of age. J Sports Sci 2014;32:652-9.

Laukkanen JA, Willeit P, Kurl S, Mäkikallio TH, Savonen K, Ronkainen K, Rauramaa R. Elevated systolic blood pressure during recovery from exercise and the risk of sudden cardiac death. J Hypertens 2014;32:659-66.

Khan H, Kunutsor S, Rauramaa R, Savonen K, Kalogeropoulos AP, Georgiopoulou VV, Butler J, Laukkanen JA. Cardiorespiratory fitness and risk of heart failure: a population-based follow-up study. Eur J Heart Fail 2014;16:180-8.

McLeod O, Silveira A, Fredrikson GN, Gertow K, Baldassarre D, Veglia F, Sennblad B, Strawbridge RJ, Larsson M, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Humphries SE, Tremoli E, de Faire U, Ohrvik J, Nilsson J, Hamsten A. Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis. Atherosclerosis 2014;232:242-8.

2013

Hu YJ, …, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, … Rauramaa R, Lakka TA, … et al. Meta-analysis of gene-level associations for rare variants based on single-variant statistics. Am J Hum Genet 2013; 93(2):236-48.

Do R, … Komulainen P, … Lakka TA, …, Rauramaa R, … et.al. Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet 2013;45:1345-52.

Global Lipids Genetics Consortium, Willer CJ, …, Komulainen P, …, Lakka TA, …, Rauramaa R, … et al. Discovery and refinement of loci associated with lipid levels. Nat Genet 2013;45:1274-83.

Deleskog A, Piksasova O, Silveira A, Gertow K, Baldassarre D, Veglia F, Sennblad B, Strawbridge RJ, Larsson M, Leander K, Gigante B, Kauhanen J, Rauramaa R, Smit AJ, Mannarino E, Giral P, Gustafsson S, Östenson CG, Humphries SE, Tremoli E, de Faire U, Öhrvik J, Hamsten A. Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis. Arterioscler Thromb Vasc Biol 2013;33:2633-8.

Heikkilä HM, Krachler B, Savonen K, Hassinen M, Rauramaa R, Schwab US. Combined low-saturated fat intake and high fitness may counterbalance diabetogenic effects of obesity: the DR’s EXTRA Study. Eur J Clin Nutr 2013;67:1000-2.

Baldassarre D, Veglia F, Hamsten A, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Grossi E, Paoletti R, Tremoli E; IMPROVE Study Group. Progression of carotid intima-media thickness as predictor of vascular events: results from the IMPROVE study. Arterioscler Thromb Vasc Biol 2013;33:2273-9.

Randall JC, …, Lakka TA, Rauramaa R, … et.al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet 2013;9(6):e1003500.

Kuvaja-Köllner V, Valtonen H, Komulainen P, Hassinen M, Rauramaa R. The impact of time cost of physical exercise on health outcomes by older adults: the DR’s EXTRA Study. Eur J Health Econ 2013;14:471-9.

Laukkanen JA, Rauramaa R. Systolic blood pressure during exercise testing and the risk of sudden cardiac death. Int J Cardiol 2013;168:3046-7.

Berndt SI, …, Lakka TA, …, Rauramaa R, … et.al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet 2013;45:501-12.

Wu Y, … Komulainen P, …, Lakka TA, …, Rauramaa R, … et al. Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet 2013;9:e1003379.

Kivipelto M, Solomon A, Ahtiluoto S, Ngandu T, Lehtisalo J, Antikainen R, Bäckman L, Hänninen T, Jula A, Laatikainen T, Lindström J, Mangialasche F, Nissinen A, Paajanen T, Pajala S, Peltonen M, Rauramaa R, Stigsdotter-Neely A, Strandberg T, Tuomilehto J, Soininen H. The finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER): study design and progress. Alzheimers Dement 2013;9:657- 65.

Harrison SC, …, Rauramaa R, … et al. A gene-centric study of common carotid artery remodelling.  Atherosclerosis 2013;226:440-6.

Krachler B, Völgyi E, Savonen K, Tylavsky FA, Alén M, Cheng S. BMI and an anthropometry-based estimate of fat mass percentage are both valid discriminators of cardiometabolic risk: a comparison with DXA and bioimpedance. J Obes 2013;2013:862514.

2012

Gertow K, … Rauramaa R… Savonen K et al. Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. Circ Cardiovasc Genet 2012;(6):656-65.

Baldassarre D, Hamsten A, Veglia F, de Faire U, Humphries SE, Smit AJ, Giral P, Kurl S, Rauramaa R, Mannarino E, Grossi E, Paoletti R, Tremoli E; IMPROVE Study Group. Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events: results of the IMPROVE (Carotid intima media thickness [IMT] and IMT-progression as predictors of vascular events in a high risk european population) study. J Am Coll Cardiol 2012;(16):1489-99.

Nyyssönen K, Kurl S, Karppi J, Nurmi T, Baldassarre D, Veglia F, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries S, Giral P, Grossi E, Tremoli E. LDL oxidative modification and carotid atherosclerosis: results of a multicenter study. Atherosclerosis 2012;(1):231-6.

Helgadottir A, … Rauramaa R … et al. Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol 2012;(8):722-9.

Scott RA, … Rauramaa R … et al. Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet 2012;(9):991-1005.

Morris AP, … Rauramaa R … et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 2012;(9):981-90.

Manning AK, … Rauramaa R,… et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012;(6):659-69.

Haapala I, Prättälä R, Patja K, Männikkö R, Hassinen M, Komulainen P, Rauramaa R. Age, marital status & changes in dietary habits in later life: a 21-year follow-up among finnish women. Public Health Nutr 2012;(7):1174-81.

Heikkilä HM, Schwab U, Krachler B, Männikkö Rand Rauramaa R. Dietary associations with prediabetic states---The DR’s EXTRA Study (ISRCTN45977199): Eur J Clin Nutr 2012;(7):819 – 824.

Savonen K, Krachler B, Hassinen M, Komulainen P, Kiviniemi V, Lakka TA, Rauramaa R. The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study. Int J Obes 2012;(8):1135-40.

Kouki R, Schwab U, Lakka TA, Hassinen M, Savonen K, Komulainen P, Krachler B, Rauramaa R. Diet, fitness and metabolic syndrome- the DR’s EXTRA Study. Nutr Metab Cardiovasc Dis 2012;(7):553-60.

Penttilä I. Halonen T, Pakkanen A. HbA1c-analytiikan laatutavoitteet diabeteksen hoidon seurannassa ja diagnostiikassa. Moodi 2012;36:269-273.

Penttilä I. Halonen T. Diabeteksen nykyinen laboratoriodiagnostiikka. Kliin Lab 2012;29:100-103.

Laitinen H, Penttilä I. HbA1c:n tuleva yksikkö mmol/mol. Kliin Lab 2012;29:130.

2011

Sanna S, Li B, Mulas A, Sidore C, Kang HM, Jackson AU, Piras MG, Usala G, Maninchedda G, Sassu A, Serra F, Palmas MA, Wood WH 3rd, Njølstad I, Laakso M, Hveem K, Tuomilehto J, Lakka TA, Rauramaa R, Boehnke M, Cucca F, Uda M, Schlessinger D, Nagaraja R, Abecasis GR. Fine mapping of five loci associated with low-density lipoprotein cholesterol detects variants that double the explained heritability. PLoS Genet 2011;7(7):e1002198.

Savonen KP, Kiviniemi V, Laaksonen DE, Lakka TA, Laukkanen JA, Tuomainen TP, Rauramaa R. Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men. J Intern Med 2011;270:589-96.

Calabresi L, Baldassarre D, Simonelli S, Gomaraschi M, Amato M, Castelnuovo S, Frigerio B, Ravani A, Sansaro D, Kauhanen J, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral P, Veglia F, Sirtori CR, Franceschini G, Tremoli E. Plasma lecithin: cholesterol acyltransferase and carotid intima-media thickness in European individuals at high cardiovascular risk. J Lipid Res 2011;52(8):1569-74.

Penttilä I, Penttilä K, Halonen T, Pulkki K, Törrönen J, Rauramaa R. Adaptiation of the Diazyme Direct Enzymatic HbA1c Assay for a microplate reader at room temperature. Clin Chem Lab Med 2011;49(7):1221-3.

Kouki R, Schwab U, Hassinen M, Komulainen P, Heikkilä H, Lakka TA, Rauramaa R. Food consumption, nutrient intake and the risk of having metabolic syndrome: the DR's EXTRA Study. Eur J Clin Nutr 2011;65(3):368-77.

Döring F, Onur S, Kürbitz C, Boular MR, Pérusse L, Rankinen T, Rauramaa R, Wolfarth B, Bouchard C. Single nucleotide polymorphisms in the myostatin (MSTN) and muscle craetine kinase (CKM) genes are not associated with elite endurance performance. Scand J Med Sci Sports 2011;21(6):841-5.

Hakola L, Komulainen P, Hassinen M, Savonen K, Litmanen H, Lakka TA, Rauramaa R. Cardiorespiratory fitness in aging men and women: the DR’s EXTRA study. Scand J Med Sci Sports 2011;21(5):679-87.

Penttilä I, Halonen T. HbA1c:n rinnakkaistulostuksesta luopuminen ja uudet laadunvalvonnan tavoiterajat. Kliin Lab 2011;6:117.

Laukkanen JA, Rauramaa R, Mäkikallio TH, Toriola AT, Kurl S. Intensity of leisure-time physical activity and cancer mortality in men. Br J Sports Med 2011;45:125-9.

2010

Döring FE, Onur S, Geisen U, Boulay MR, Perusse L, Rankinen T, Rauramaa R, Wolfahrt B, Bouchard C. ACTN3 R577X and other polymorphisms are not associated with elite endurance athlete status in the Genathlete study. J Sports Sci 2010;28(12):1355-9.

Laukkanen JA, Mäkikallio TH, Rauramaa R, Kiviniemi V, Ronkainen K, Kurl S. Cardiorespiratory fitness is related to the risk of sudden cardiac death: a population-based follow-up study. J Am Coll Cardiol 2010;56(18):1476-83.

Länsimies-Antikainen H, Pietilä AM, Laitinen T, Kiviniemi V, Rauramaa R. Is informed consent related to success in exercise and diet intervention as evaluated at 12 months? DR's EXTRA study. BMC Med Ethics 2010;11:9.

Hassinen M, Lakka TA, Hakola L, Savonen K, Komulainen P, Litmanen H, Kiviniemi V, Kouki R, Heikkilä H, Rauramaa R. Cardiorespiratory fitness and metabolic syndrome in older men and women: the Dose Responses to Exercise Training (DR's EXTRA) study. Diabetes care 2010;33(7):1655-7.

Komulainen P, Kivipelto M, Lakka TA, Savonen K, Hassinen M, Kiviniemi Y, Hänninen T, Rauramaa R. Exercise, fitness and cognition – A randomised controlled trial in older individuals: The DR's EXTRA study. Eur Geriatr Med 2010;1:266-272.

Savonen K. Liikkumattomasta liikkujaksi - hitaasti kiihdyttäen. Liikunta ja tiede 2010;47(5):28-31.

Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Mursu J, Savonen K, Lakka TA, Niskanen L, Kauhanen J. Sedentary lifestyle and emergence of hopelessness in middle-aged men. Eur J Cardiovasc Prev Rehabil 2010;17(5):524-9.

Döring F, Onur S, Fischer A, Boulay MR, Pérusse L, Rankinen T, Rauramaa R, Wolfarth B, Bouchard C. A common haplotype and the Pro582Ser polymorphism of the hypoxia-inducible factor-1alpha (HIF1A) gene in elite endurance athletes. J Appl Physiol 2010;108(6):1497-500.

Baldassarre D, Nyyssönen K, Rauramaa R, de Faire U, Hamsten A, Smit AJ, Mannarino E, Humphries SE, Giral G, Grossi E, Veglia F, Paoletti R, Tremoli E, on behalf of the IMPROVE study group. Cross-sectional analysis of baseline data to identify the major determinants of carotid intima–media thickness in a European population: the IMPROVE study. Eur Heart J 2010; 31, 614–622.

Länsimies-Antikainen H, Pietilä AM, Kiviniemi V, Rauramaa R, Laitinen T. Evaluation of participant comprehension of information received in an exercise and diet intervention trial: The DR's EXTRA study. Gerontology 2010;56(3):291-7.

Laukkanen JA, Pukkala E, Rauramaa R, Mäkikallio TH, Toriola AT, Kurl S. Cardiorespiratory fitness, lifestyle factors and cancer risk and mortality in finnish men. Eur J Cancer 2010;46:355-363.

Länsimies-Antikainen H, Laitinen T, Rauramaa R, Pietilä AM. Evaluation of informed consent in health research: a questionnaire survey. Scand J Caring Sci 2010;24(1):56-64.

2009

Karppi J, Åkerman S, Åkerman K, Kontturi K, Nyyssönen K, Penttilä I. Suitability of Smopex® -102 cation-exchange fiber for analytical purposes and drug monitoring. Die Pharmazie 2009;64:14-18.

Valtonen M, Laaksonen DE, Laukkanen J, Tolmunen T, Rauramaa R, Viinamäki H, Kauhanen J, Lakka T, Niskanen L. Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men. BMC Public Health 2009;25;9:204.

Laukkanen JA, Laaksonen D, Lakka TA, Savonen K, Rauramaa R,Mäkikallio T, Kurl S. Determinants of cardiorespiratory fitness in men aged 42 to 60 years with and without cardiovascular disease. Am J Cardiol 2009;103(11):1598-604.

Laukkanen JA, Mäkikallio T, Rauramaa R, Kurl S. Asymptomatic St-segment depression during exercise testing and the risk of sudden cardiac death in middle-aged men: a population-based follow-up study. Eur Heart J 2009;30(5):558-65.

Kurl S, Sivenius J, Mäkikallio T, Rauramaa R, Laukkanen. A. Exercise workload, cardiovascular risk factor evaluation and the risk of stroke in middle-aged men. J Inter Med 2009;265(2):229-37.

2008

Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R. BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study. Neurobiol Learn Mem 2008;90(4):596-603.

de Mello VD, Kolehmainen M, Pulkkinen L, Schwab U, Mager U, Laaksonen DE, Niskanen L, Gylling H, Atalay M, Rauramaa R, Uusitupa M. Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study. Diabetologia 2008;51(11):2060-7.

Savonen KP, Kiviniemi V, Laukkanen JA, Lakka TA, Rauramaa TH, Salonen JT, Rauramaa R. Chronotropic incompetence and mortality in middle-aged men with known or suspected coronary heart disease. Eur Heart J 2008;29(15):1896-902.

Laukkanen JA, Rauramaa R, Kurl S. Exercise workload, coronary risk evaluation and the risk of cardiovascular and all-cause death in middle-aged men. Eur J Cardiovasc Prev Rehabil 2008;15(3):285-92.

Hassinen M, Lakka TA, Savonen K, Litmanen H, Kiviaho L, Laaksonen DE, Komulainen P, Rauramaa R. Cardiorespiratory fitness as a feature of the metabolic syndrome in older men and women: The DR's EXTRA Study. Diabetes Care 2008;31:1242-7.

Laaksonen DE, Niskanen L, Mykkänen H, Juntunen KS, Schwab U, Kolehmainen M, Rauramaa R, Tuomilehto J, Uusitupa M. Long-term repeatability of measures of early insulin secretion derived from an intravenous glucose tolerance test and conversion from impaired glucose tolerance to diabetes. Ann Med 2008;40:303-11.

Mager U, Kolehmainen M, de Mello VD, Schwab U, Laaksonen DE, Rauramaa R, Gylling H, Atalay M, Pulkkinen L, Uusitupa M. Expression of ghrelin gene in peripheral blood mononuclear cells and plasma ghrelin concentrations in patients with metabolic syndrome. Eur J Endocrinol 2008;158:499–510.

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Usefulness of chronotropic incompetence in response to exercise as a predictor of myocardial infarction in middle-aged men without cardiovascular disease. Am J Cardiol 2008;101:992-8.

Lappalainen T, Kolehmainen M, Schwab U, Pulkkinen L, Laaksonen DE, Rauramaa R, Uusitupa M, Gylling H. Serum concentrations and expressions of serum amyloid A and leptin in adipose tissue are interrelated: the Genobin Study. Eur J Endocrinol 2008;158:333-41.

de Mello VD, Kolehmainen M, Schwab U, Mager U, Laaksonen DE, Pulkkinen L, Niskanen L, Gylling H, Atalay M, Rauramaa R, Uusitupa M. Effect of weight loss on cytokine messenger RNA expression in peripheral blood mononuclear cells of obese subjects with the metabolic syndrome. Metabolism 2008;57:192-9.

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease. Heart 2008;94(4):e14.

Kolehmainen M, Salopuro T, Schwab U S, Kekäläinen J , Kallio P, Laaksonen DE, Pulkkinen L,  Lindi V I , Sivenius K,  Mager U, Siitonen N,  Niskanen L,  Gylling H, Rauramaa R, Uusitupa M. Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study. Int J Obes (Lond) 2008;32:292-303.

Wolfarth B, Rankinen T, Mühlbauer S, Ducke M, Rauramaa R, Boulay MR, Pérusse L, Bouchard C. Endothelial nitric oxide synthase gene polymorphism and elite endurance athlete status: the Genathlete study. Scand J Med Sci Sports 2008;18(4):485-90.

Penttilä IM. Tulevatko apolipoproteiinimääritykset syrjäyttämään kolesterolimääritykset? Kliin Lab 2008;25:49-50.

Laaksonen DE, Niskanen L, Nyyssönen K, Lakka TA, Laukkanen JA, Salonen JT. Dyslipidaemia as a predictor of hypertension in middle-aged men. Eur Heart J 2008;29(20): 2561–2568.

Kilpeläinen TO, Lakka TA, Laaksonen DE, Mager U, Salopuro T, Kubaszek A, Todorova B, Laukkanen O, Lindström J, Eriksson JG, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M. Finnish diabetes prevention study group. Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention Study. Metabolism 2008;57(3):428-36.

Wadén J, Forsblom C, Thorn LM, Saraheimo M, Rosengård-Bärlund M, Heikkilä O, Lakka TA, Tikkanen H, Groop PH; FinnDiane Study Group. Physical activity and diabetes complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study. Diabetes Care 2008;31:230-2.

Kilpeläinen TO, Lakka TA, Laaksonen DE, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Lindi V, Tuomilehto J, Uusitupa M, Laakso M. SNPs in PPARG associate with type 2 diabetes and interact with physical activity. Med Sci Sports Exerc 2008;40:25-33.

Penttilä IM, Savolainen K, Lampinen H, Lukkarinen J. Easily Applicable Myoglobin Method on the KonelabTM Analyzer. Klinisk Biokemi i Norden 2008;20:44-46.

2007

Wolfarth B, Rankinen T, Mühlbauer S, Scherr J, Boulay MR, Pérusse L, Rauramaa R, Bouchard C. Association between a beta2-adrenergic receptor polymorphism and elite endurance performance. Metabolism 2007;56:1649-51.

Kilpeläinen TO, Lakka TA, Laaksonen DE, Laukkanen O, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Aunola S, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Uusitupa M, Laakso M; Finnish Diabetes Prevention Study Group. SNPs in PPARG associate with type 2 diabetes and interact with physical activity (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics 2007;31:264-72.

Hu G, Jousilahti P, Borodulin K, Barengo NC, Lakka TA, Nissinen A, Tuomilehto J. Occupational, commuting and leisure-time physical activity in relation to coronary heart disease among middle-aged Finnish men and women. Atherosclerosis 2007;194:490-7.

Komulainen P, Kivipelto M, Lakka TA, Hassinen M, Helkala EL, Patja K, Nissinen A, Rauramaa R. Carotid intima-media thickness and cognitive function in elderly women: a population-based study. Neuroepidemiology 2007;28:207-213.

Karppi J, Kerman S, Kerman K, Sundell A, Nyyssonen K, Penttila I. Isolation of drugs from biological fluids by using pH sensitive poly(acrylic acid) grafted poly(vinylidene fluoride) polymer membrane in vitro. Eur J Pharm Biopharm 2007;67:562-8.

Hassinen M, Lakka TA, Komulainen P, Haapala I, Nissinen A, Rauramaa R. Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women. Int J Obes (Lond) 2007;31:1406-11.

Penttilä IM, Laatikainen A, Penttila K, Punnonen K, Rantanen T, Savolainen K, Tiikkainen U. Imprecision of cardiac marker analyses among laboratories on the basis of external quality assurance results: Finnish experience. Scand J Clin Lab Invest 2007;67:507-18.

Savonen KP, Lakka TA, Laukkanen JA, Rauramaa TH, Salonen JT, Rauramaa R. Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline. Am J Cardiol 2007;100:563-8.

Laukkanen JA, Rauramaa R, Salonen JT, Kurl S. The predictive value of cardiorespiratory fitness combined with coronary risk evaluation and the risk of cardiovascular and all-cause death. J Intern Med 2007;262:263-72.

Hallikainen M, Kolehmainen M, Schwab U, Laaksonen DE, Niskanen L, Rauramaa R, Pihlajamäki J, Uusitupa M, Miettinen TA, Gylling H. Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome. Clin Chim Acta 2007;383:126-32.

Karppi J, Akerman S, Akerman K, Sundell A, Nyyssonen K, Penttila I. Adsorption of drugs onto a pH responsive poly(N,N-dimethyl aminoethyl methacrylate) grafted anion-exchange membrane in vitro. Int J Pharm 2007;338:7-14.

Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamäki J, Mykkänen H, Ågren JJ, Rauramaa R, Laakso M, Miettinen TA. Cholesterol synthesis prevails over absorption in metabolic syndrome. Transl Res 2007;149:310-6.

Länsimies-Antikainen H, Pietilä AM, Laitinen T, Schwab U, Rauramaa R, Länsimies E. Evaluation of informed consent: a pilot study. J Adv Nurs 2007;59:146-54.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing 2007;36:443-8.

Komulainen P, Lakka TA, Kivipelto M, Hassinen M, Helkala EL, Haapala I, Nissinen A, Rauramaa R. Metabolic  syndrome and cognitive function: a population-based follow-up study in elderly women. Dement Geriatr Cogn Disord 2007;23:29-34.

2006

Hallikainen M, Lyyra-Laitinen T, Laitinen T, Pihlajamäki J, Rauramaa R, Miettinen TA, Gylling H. Endothelial function in hypercholesterolemic subjects: effects of plant stanol and sterol esters. Atherosclerosis 2006;188:425-32.

Laukkanen JA, Kurl S, Salonen JT, Lakka TA, Rauramaa R. Peak oxygen pulse during exercise as a predictor for coronary heart disease and all-cause death in men. Heart 2006;92:1219-24.

Laukkanen JA, Kurl S, Rauramaa R, Lakka TA, Venäläinen JM, Salonen JT. Systolic blood pressure response to exercise testing is related to the risk of acute myocardial infarction in middle-aged men. Eur J Cardiov Prev R 2006;13:421-428.

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. C-reactive protein and metabolic syndrome in elderly women. A 12-year follow-up study. Diabetes Care 2006;29:931-2.

Savonen K, Lakka TA, Laukkanen J, Rauramaa T, Salonen JT, Rauramaa R. Heart rate response during exercise test and cardiovascular mortality in middle-aged men. Eur Heart J 2006;27:582-8.

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Haapala I, Gylling H, Alen M, Schmidt-Trucksäss A, Nissinen A, Rauramaa R. Metabolic syndrome and the progression of carotid intima-media thickness in elderly women. Arch Int Med 2006;166:444-9.

2005

Penttilä IM, Halonen T, Punnonen K, Tiikkainen U. Best use of the recommended IFCC reference method, material and values in HbA1C analyses. Scand J Clin Lav Invest 2005;65:453-462.

Tuomainen P, Peuhkurinen K, Kettunen R, Rauramaa R. Regular physical exercise, heart rate variability and turbulence in a 6-year randomized controlled trial in middle-aged men: The DNASCO Study. Life Sci 2005;77:2723-34.

Remes T, Väisänen SB, Mahonen A, Huuskonen J, Kröger H, Jurvelin JS, Rauramaa R. Bone mineral density, body height, and vitamin D receptor gene polymorphism in middle-aged men. Ann Med 2005;37:383-392.

Hassinen M, Komulainen P, Lakka TA, Väisänen SB, Rauramaa R. Associations of body composition and physical activity with balance and walking ability in the elderly. J Phys Act Health 2005;3:298-306.

Kurl S, Laukkanen JA, Niskanen L, Rauramaa R, Tuomainen TP, Sivenius J, Salonen JT. Cardiac power during exercise and the risk of stroke. Stroke 2005;36:820-4.

2004

Laukkanen JA, Kurl S, Salonen R, Lakka TA, Rauramaa R, Salonen JT. Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men.  Hypertension 2004;44:820-825.

Laukkanen JA, Kurl S, Salonen R, Rauramaa R, Salonen JT. The predictive value of cardiorespiratory fitness for cardiovascular events in men with various risk profiles: a prospective population-based cohort study. Eur Heart J 2004;25:1428-37.

Remes T, Väisänen SB, Mahonen A, Huuskonen J, Kroger H, Jurvelin JS, Penttila IM, Rauramaa R. The association of bone metabolism with bone mineral density, serum sex hormone concentrations, and regular exercise in middle-aged men. Bone 2004;35:439-47.

Gylling H, Hallikainen M, Pihlajamäki J,  Ågren J, Laakso M,  Rajaratnam R , Rauramaa R, Miettinen TA. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res 2004;45:1660-5.

Rauramaa R, Halonen P, Väisänen SB, Lakka TA, Schmidt-Trucksäss A, Berg A, Penttilä IM, Rankinen T, Bouchard C. Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial. Ann Intern Med 2004;140:1007-1014.

Uusitalo AL, Laitinen T, Väisänen SB, Länsimies E, Rauramaa R. Physical training and heart rate and blood pressure variability - a five-year randomized trial. Am J Physiol Heart Circ Physiol 2004;286:H1821-6.

Penttilä I, Tiikkainen U. Glykoituneen hemoglobiinin määritykset ja niiden laatu sekä analyysien tulevaisuuden näkymät Suomessa. Kliin Lab 2004;21:99-102.

2003

Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Salonen R, Rauramaa R, Salonen JT. Sex hormones, inflammation and the metabolic syndrome: a population-based study. Eur J Endocrinol 2003;149:601-8.

Karpansalo M, Lakka TA, Manninen P, Kauhanen J, Rauramaa R, Salonen JT. Cardiorespiratory fitness and risk of disability pension: a prospective population based study in Finnish men. Occup Environ Med 2003;60:765-9.

Lakka TA, Laaksonen DE, Lakka H-M, Mannikko N, Niskanen LK, Rauramaa R, Salonen JT. Sedentary lifestyle, poor cardiorespiratory fitness and the metabolic syndrome. Med Sci Sports Exerc 2003;35:1279-86.

Kurl S, Laukkanen JA, Tuomainen T-P, Rauramaa R, Lakka TA, Salonen JT, Eränen J, Sivenius J, Salonen JT. Association of exercise-induced silent ST-segment depression with the risk of stroke and cardiovascular diseases in men. Stroke 2003;34:1760-5.

Laaksonen DE, Lakka H-M, Lynch J, Lakka TA, Niskanen L, Rauramaa R, Salonen JT, Kauhanen J. Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome. Diabetes Care 2003;26:2156-64.

Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Cardiorespiratory fitness and the risk of stroke in men. Arch Intern Med 2003;163:1682-8.

Lakka TA, Rankinen T, Weisnagel SJ, Chagnon YC, Rice T, Leon AS, Skinner JS, Wilmore JH, Rao DC, Bouchard C. A Quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study. Diabetes 2003;52:1583-7.

König D, Väisänen SB, Bouchard C, Halle M, Lakka TA, Baumstark MW, Alen M, Berg A, Rauramaa R. Cardiorespiratory fitness modifies the association between dietary fat intake and plasma fatty acids. Eur J Clin Nutr 2003;57:810-815.

Remes T, Väisänen SB, Mahonen A, Huuskonen J, Kröger H, Jurvelin JS, Penttilä IM, Rauramaa R. Aerobic exercise and bone mineral density in middle-aged Finnish men: a controlled randomized trial with reference to androgen receptor, aromatase, and estrogen receptor a gene polymorphisms. Bone 2003;32:412-420.

Schmidt-Trücksäss A, Sandrock M, Cheng da C, Müller HM, Baumstark MW, Rauramaa R, Berg A, Huonker M. Quantative measurement of carotid intima-media roughness - effect of age and manifest coronary artery disease. Atherosclerosis 2003;166:57-65.

2002

Karpansalo M, Manninen P, Lakka TA, Kauhanen J, Rauramaa R, Salonen JT. Physical workload and risk of early retirement: prospective population-based study among middle-aged men. J Occup Environ Med 2002;44:930-9.

Laaksonen DE, Lakka HM, Salonen JT, Niskanen LK, Rauramaa R, Lakka TA. Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care 2002;25:1612-1618.

Rauramaa R, Kuhanen R, Lakka TA, Väisänen SB, Halonen P, Alen M, Rankinen T, Bouchard C. Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism. Physiol Genomics 2002;10:71-77.

Huuskonen J, Väisänen SB, Kröger H, Jurvelin JS, Penttilä I, Alhava E, Rauramaa R. The relation of sex hormones to bone mineral density in middle-aged men during a four year exercise intervention trial. Bone 2002;31:51-6.

Uusitalo ALT, Laitinen T, Väisänen SB, Länsimies E, Rauramaa R. Effects of endurance training on heart rate and blood pressure variability. Clin Physiol Funct Imaging 2002;22:173-179.

Hassinen M, Komulainen P. Kevytkuormitteisen aerobisen liikunnan vaikutus lihasvoimaan, nivelten liikkuvuuteen ja tasapainoon keski-ikäisillä miehillä. Fysioterapia 2002;4:25-29.

2001

Schmidt-Trucksäss A, Cheng Dc D, Sandrock M, Schulte-Mönting J, Rauramaa R, Huonker M, Burkhardt H. Computerized analysing system using the active contour in ultrasound measurement of carotid artery intima-media thickness. Clin Physiol 2001;21:561-569.

Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Systolic blood pressure response to exercise stress test and risk of stroke. Stroke 2001;32:2036-2041.

Laukkanen JA, Kurl S, Lakka TA, Tuomainen TP, Rauramaa R, Salonen R, Eränen J, Salonen JT. Exercise-induced silent myocardial ischemia and coronary morbidity and mortality in middle-aged men.  J Am Coll Cardiol 2001;38:72-79.

Huuskonen J, Väisänen SB, Kröger H, Jurvelin JS, Alhava E, Rauramaa R. Regular physical exercise and bone mineral density: a four-year controlled randomized trial in middle-aged men. The DNASCO study. Osteoporos Int 2001;12:349-355.

Laukkanen JA, Lakka TA, Rauramaa R, Kuhanen R, Venäläinen JM, Salonen R, Salonen JT. Cardiovascular fitness as a predictor of mortality in men. Arch Intern Med 2001;161:825-831.

Lakka T, Laukkanen J, Rauramaa R, Salonen R, Lakka H-M, Kaplan G, Salonen J. Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men. Ann Intern Med 2001;134:12-20.

2000

Rauramaa R, Väisänen S, Luong L-A, Schmidt-Trücksäss A, Penttilä I, Bouchard C, Töyry J, Humphries S. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. Arterioscler Thromb Vasc Biol 2000;20:2657-2662.

Niskanen L, Karvonen M, Valve R, Koulu M, Pesonen U, Mercuri M, Rauramaa R, Töyry J, Laakso M, Uusitupa M. Leucine 7 to proline 7 polymorphism in the neuropeptide Y gene is associated with enhanced carotid atherosclerosis in elderly patients with type 2 diabetes and control subjects. J Clin Endocrinol Metab 2000;85:2266-9.

Huuskonen J, Väisänen S, Kröger H, Jurvelin C, Bouchard C, Alhava E, Rauramaa R. Determinants of bone mineral density in middle aged men: a population-based study. Osteoporos Int 2000;11:702-708.

Rauramaa R, Väisänen S, Kuhanen R, Penttilä I, Bouchard C. The RsaI polymorphism in the alpha-fibrinogen gene and response of plasma fibrinogen to physical training - a  controlled randomised clinical trial in men. Thromb Haemost 2000;83:803-6.

Rankinen T, Hietanen E, Väisänen S, Lehtiö M, Penttilä I, Bouchard C, Rauramaa R. Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men. Thromb Res 2000;99:453-459.

Rankinen T, Wolfarth B, Simoneau J-A, Maier-Lenz D, Rauramaa R, Rivera M, Boulay M, Chagnon Y, Perusse L, Keul J, Bouchard C. No association between the angiotensin-converting enzyme ID polymorphism and elite endurance athlete status. J Appl Physiol 2000;88:1571-1575.

1999

Korhonen MH, Litmanen H, Rauramaa  R, Väisänen SB, Niskanen L, Uusitupa M. Adherence to the salt restriction diet among people with mildly elevated blood pressure. Eur J Clin Nutr 1999;53:880-5.

Väisänen SB, Humphries SE, Luong LA, Penttilä I, Bouchard C, Rauramaa R. Regular exercise, plasminogen activator inhibitor-1 (PAI-1) activity and the 4G/5G promoter polymorphism in the PAI-1 gene. Thromb Haemost 1999;82:1117-1120.

Helminen A, Rankinen T, Halonen P, Väisänen S, Rauramaa R. Positive and negative life changes and LDL cholesterol. J Biosoc Sci 1999;31:269-277.

1998

Rankinen T, Lyytikäinen S, Vanninen E, Penttilä I, Rauramaa R, Uusitupa M. Nutritional status of the Finnish elite ski jumpers. Med Sci Sports Exerc 1998;30:1592-1597.

Vanninen E, Mussalo H, Vainio P, Tuomainen P, Ikonen A, Kettunen R, Rauramaa R, Kuikka JT. Sydänlihaksen perfuusion gammakuvauksen uusia mahdollisuuksia: viitearvot ja EKG-tahdistettu yksifotoniemissio-tomografia. Lääkärilehti 1998;53:141-147.

1997

Väisänen S, Baumstark M,Penttilä I, Bouchard C, Halonen P, Rankinen T, Berg A, Rauramaa R. Small, dense LDL particle concentration correlates with plasminogen activator inhibitor type-1 (PAI-1) activity. Thromb Haemost 1997;78:1495-9.

Vauhkonen I, Niskanen L, Ryynänen M, Voutilainen R, Partanen J, Mercuri M, Rauramaa R, Töyry J, Uusitupa M. Divergent association of apolipoprotein E polymorphism with vascular disease in patients with NIDDM and control subjects. Diabet Med 1997;14:748-756.

Rauramaa R, Väisänen S, Nissinen A, Rankinen T, Penttilä I, Saarikoski S,Tuomilehto J, Gagnon J, Pérusse L, Bouchard C. Physical activity, fibrinogen plasma level and gene polymorphisms in postmenopausal women. Thromb Haemost 1997;78:840-4.

Rankinen T, Suomela-Markkanen T, Väisänen S, Helminen A, Penttilä I, Berg A, Bouchard C, Rauramaa R. Relationship between the changes in physical activity and plasma insulin during a 2.5 year follow-up study. Metabolism 1997;46:1418-23.

Väisänen S, Rauramaa R, Penttilä I, Rankinen T, Gagnon J,  Pérusse L,  Chagnon M, Bouchard C. Variation in plasma fibrinogen over one year: relationships with genetic polymorphisms and non-genetic factors. Thromb Haemost 1997;77:884-9.

Eronen M, Rankinen T, Halonen P, Sulkava R, Rauramaa R, Nissinen A. Does aging mean a better life for women? J Am Geriatr Soc 1997;45:594-7.

Helminen A, Rankinen T, Väisänen S, Rauramaa R. Social network in relation to plasma fibrinogen. J Biosoc Sci 1997;29:129-39.

Ågren JJ, Väisänen S, Hänninen O, Muller AD, Hornstra G. Hemostatic factors and platelet aggregation after a fish-enriched diet or fish oil or docosahexaenoic acid supplementation. Prostag Leukotr Ess 1997;57:419-21.

1996

Niskanen L, Rauramaa R, Miettinen H, Haffner SM, Mercuri M, Uusitupa M. Carotid artery intima-media thickness in elderly patients with NIDDM and in nondiabetic subjects. Stroke 1996;27:1986-1992.

Uusitupa MIJ, Niskanen L, Luoma J, Vilja P, Mercuri M, Rauramaa R, Ylä-Herttuala S. Autoantibodies against oxidized LDL do not predict atherosclerotic vascular disease in non-insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol 1996;16:1236-1242.

Väisänen S, Rauramaa R, Rankinen T, Gagnon J, Bouchard C. Physical activity, fitness, and plasma fibrinogen with reference to fibrinogen genotypes. Med Sci Sports Exerc 1996;28:1165-1170.

Uusitupa M, Korhonen M, Litmanen H, Niskanen L, Väisänen S, Rauramaa R. Effects of moderate salt restriction alone and in combination with cilazapril on office and ambulatory blood pressure. J Hum Hypertens 1996;10:319-326. 

1995

Helminen A, Rankinen T, Mercuri M, Rauramaa R. Carotid atherosclerosis in middle-aged men. Relation to conjugal circumstances and social support. Scand J Soc Med 1995;23:167-72.

Rankinen T, Fogelmholm M, Kujala U, Rauramaa R, Uusitupa M. Dietary intake and nutritional status of athletic and nonathletic children in early puberty. Int J Sport Nutr 1995;5:136-50.

Pekkanen J, Mutanen M, Räsänen L, Rauramaa R, Nissinen A. Association of factor VII activity with dietary fat and blood lipids among elderly men - The Finnish cohorts of the Seven Countries Study. Nutr Metab Cardiovasc Dis 1995;5:149-154.

Rauramaa R, Tuomainen P, Väisänen S, Rankinen T. Physical activity and health-related fitness in middle-aged men. Med Sci Sports Exerc 1995;27:707-712.

Väisänen S, Rankinen T, Penttilä I, Rauramaa R. Factor VII coagulant activity in relation to serum lipoproteins and dietary fat in middle-aged men. Thromb Haemost 1995;73:435-8.

Rankinen T, Väisänen S, Penttilä I, Rauramaa R. Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost 1995;73:281-286.

Rauramaa R, Väisänen SB, Rankinen T, Penttilä IM, Saarikoski S, Tuomilehto J, Nissinen A. Inverse relation of physical activity and apolipoprotein AI to blood pressure in elderly women. Med Sci Sports Exerc 1995;27:164-169.

Rauramaa R, Rankinen T, Tuomainen P, Väisänen S, Mercuri M. Inverse relationship between cardiorespiratory fitness and carotid atherosclerosis in middle-aged men. Atherosclerosis 1995;112:213-221.

Huupponen MR, Mäkinen LH, Hyvönen PM, Sen CK, Rankinen T, Väisänen S, Rauramaa R. The effect of N-acetylcysteine on exercise-induced priming of human neutrophils. A chemiluminescence study. Int J Sports Med 1995;16:399-403.

Rauramaa R, Väisänen S, Penttilä I, Rankinen T. Inverse relationship between dietary starch intake and plasma fibrinogen in middle-aged men. Nutr Metab Cardiovasc Dis 1994;4:192-196.

Helminen A, Halonen P, Rankinen T, Nissinen A, Rauramaa R. Validity assesment of a social support index. Scand J Soc Med 1995;23:66-74.

1994

Rankinen T, Väisänen S, Mercuri M, Rauramaa R. Apolipoprotein(a), Fibrinopeptide A and carotid atherosclerosis in middle-aged men. Thromb Haemost 1994;72:563-6.

Rauramaa R, Väisänen S, Mercuri M, Rankinen T, Penttilä I, Bond MG. Association of risk factors and body iron status to carotid atherosclerosis in middle-aged Eastern Finnish men. Eur Heart J 1994;15:1020-1027.

Lakka TA, Venäläinen JM, Rauramaa R, Salonen R, Tuomilehto J, Salonen JT. Relation of leisure-time physical activity and cardiorespiratory fitness to the risk of acute myocardial infarction. N Engl J Med 1994;330:1549-54.

Sen CK, Rankinen T, Väisänen S, Rauramaa R. Oxidative stress after human exercise: effect of N-acetylcysteine supplementation. J Appl Physiol 1994;76:2570-2577.

Rankinen T, Rauramaa R, Väisänen S, Penttilä IM, Uusitupa M. Relation of habitual diet and cardiorespiratory fitness to blood coagulation and fibrinolytic factors. Thromb Haemost 1994;71:180-183.

Rankinen T, Rauramaa R, Väisänen S, Halonen P, Penttilä IM. Blood coagulation and fibrinolytic factors are unchanged by aerobic exercise or fat modified diet. Fibrinolysis 1994;8:48-53.

1993

Rankinen T, Rauramaa R, Väisänen S, Penttilä I, Saarikoski S, Tuomilehto J, Nissinen A. Inverse relationship between physical activity and plasma fibrinogen in postmenopausal women. Atherosclerosis 1993;102:181-186.

1991

Salonen JT, Salonen R, Seppänen K, Rauramaa R, Tuomilehto J. HDL, HDL2, and HDL3 subfractions, and the risk of acute myocardial infarction. A prospective population study in eastern finnish men. Circulation 1991;84:129-39.

1988

Rauramaa R, Taskinen E, Seppänen K, Rissanen V, Venäläinen JM, Salonen R, Salonen JT. Effects of calcium antagonist treatment on blood pressure, lipoproteins and prostaglandins. Am J Med 1988;84:93-6.

Salonen JT, Slater J, Tuomilehto J, Rauramaa R. Leisure time and occupational physical activity: risk of death from ischemic heart disease. Am J Epidemiol 1988;127:87-94

Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppänen R, Kantola M, Seppänen K, Rauramaa R. Blood pressure, dietary fats, and antioxidants. Am J Clin Nutr 1988;48:1226-32.

Salonen JT, Salonen R, Seppänen K, Kantola M, Parviainen M, Alfthan G, Mäenpää PH, Taskinen E, Rauramaa R. Relationship of serum selenium and antioxidants to plasma lipoproteins, platelet aggregability and prevalent ischaemic heart disease in Eastern Finnish men. Atherosclerosis 1988;70:155-60.

1987

Salonen JT, Salonen R, Ihanainen M, Parviainen M, Seppänen R, Seppänen K, Rauramaa R. Vitamin C deficiency and low linolenate intake associated with elevated blood pressure. The Kuopio Ischaemic Heart Disease Risk Factor Study. J Hypertension 1987;5:S521-4.

Leon AS, Connett J, Jacobs Jr D, Rauramaa R. Leisure-time physical activity levels and risk of coronary heart disease and death. JAMA 1987;258;2388-95.

Salonen R, Nikkari T, Seppänen K, Venäläinen JM, Ihanainen M, Rissanen V, Rauramaa R, Salonen JT. Effect of omega-3 fatty acid supplementation on platelet aggregability and platelet produced thromboxane. Thromb Haemost 1987;57:269-72.

1986

Parviainen MT, Nyyssönen K, Penttilä IM, Seppänen K, Rauramaa R, Salonen JT, Gref C‑G. A method for routine assay of plasma ascorbic acid using high‑performance liquid chromatography. J Liq Chromatogr 1986;9:2185‑97.

Salonen JT, Taskinen E, Salonen R, Seppänen K, Venäläinen JM, Rauramaa R. Effects of bevantolol and atenolol on symptoms, exercise tolerance and metabolic risk factors in angina pectoris. Am J Cardiol 1986;58:35E-40E.

Rauramaa R, Salonen JT, Seppänen K, Salonen R, Venäläinen JM, Ihanainen M, Rissanen V. Inhibition of platelet aggregability by moderate‑intensity physical exercise: a randomized clinical trial in overweight men. Circulation 1986;74:939-44.

1984

Kukkonen‑Harjula K, Rauramaa R. Oxygen consumption of lumberjacks in logging with a power‑saw. Ergonomics 1984;27:59‑65.

Rauramaa R, Salonen JT, Kukkonen‑Harjula K, Seppänen K, Seppälä E, Vapaatalo H, Huttunen JK. Effects of mild physical exercise on serum lipoproteins and metabolites of arachidonic acid: a controlled randomised trial in middle aged men. Br Med J 1984;288:603-6.

1982

Kukkonen K, Rauramaa R, Siitonen O, Hänninen O. Physical training of obese middle-aged persons. Ann Clin Res 1982;14:80-5.

Kukkonen K, Rauramaa R, Voutilainen E, Länsimies E. Physical training of middle-aged men with borderline hypertension. Ann Clin Res 1982;14:139-45.

Kukkonen K, Rauramaa R, Voutilainen E, Hietanen E. Body mass index and physical fitness as determinants of serum lipoprotein levels in middle‑aged men. Clin Physiol 1982;2:251-62.

Rauramaa R. Acute effect of physical exercise on glycogen content and lipoprotein lipase activity in untrained diabetic rats. Med Biol 1982;60:139‑43.

Uusitupa M, Siitonen O, Härkönen M, Gordin A, Aro A, Hersio K, Johansson G, Korhonen T and Rauramaa R. Metabolic and hormonal response to physical exercise during beta1‑selective and nonselective beta‑blockade. Horm Metab Res 1982;14:583-8.

1980

Rauramaa R, Harri M, Puhakainen E, Kuusela P, Hänninen O. Metabolic adaptation in muscle and brown adipose tissues to insulin deficiency in streptozotocin treated rats. Comp Biochem Physiol 1980;66B:391‑5.

Rauramaa R, Kuusela P, Hietanen E. Adipose, Muscle and lung tissue lipoprotein lipase activities in young streptozotocin treated rats. Horm Metab Res 1980;12:591‑5.

Kuusela PJ, Voutilainen E, Kukkonen K, Rauramaa R. Lipoprotein patterns in lumberjacks. Scand J Sports Sci 1980;2:13‑6.

1979

Huttunen JK, Länsimies E, Voutilainen E, Ehnholm C, Hietanen E, Penttilä I, Siitonen O and Rauramaa R. Effect of moderate physical exercise on serum lipoproteins: A controlled trial with special reference to serum high density lipoproteins. Circulation 1979;60:1220-9.

1978

Komi PV, Viitasalo JT, Rauramaa R, Vihko V. Effect of isometric strength training on mechanical, electrical, and metabolic aspects of muscle function. Eur J Appl Physiol Occup Physiol 1978;40:45‑55.